{
  "schema_name": "soa-table-resolved",
  "schema_version": "1.2",
  "resolution_metadata": {
    "resolved_at": "2026-10-03T15:50:50.386788+00:00",
    "resolver": "soa2usdm.steps.resolve v1.0",
    "source_extraction": {
      "schema_name": "soa-table-extraction",
      "schema_version": "1.0",
      "extraction_file": "NCT01847274_Table_02_extraction.verified.json",
      "extraction_status": "ready_for_resolution"
    },
    "validation_results": {
      "structure_valid": true,
      "hierarchy_valid": true,
      "annotations_valid": true,
      "validation_warnings": [],
      "validation_errors": [],
      "method_provenance": [
        "indentation_level:assumed_flat: 17",
        "property_structure:inferred_from_layout: 2"
      ]
    },
    "resolution_status": "resolved",
    "ready_for_integration": true,
    "resolution_notes": ""
  },
  "extraction_metadata": {
    "extracted_at": "2026-09-27T08:38:58+00:00",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT01847274_soa.pdf",
      "document_type": "protocol",
      "document_version": "Clinical Study Protocol PR-30-5011-C Version 8"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Text-layer PDF; marks verified by pdftotext -bbox column binning against raster-recovered rule lines (200 dpi). See NCT01847274_uncertainty_report.md.",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_id": "table-002",
    "table_number": 2,
    "table_type": "track",
    "table_title": "Schedule of Events – Open-Label Food Effect Sub-Study (Study Completed)",
    "table_purpose": "Schedule for patients in the open-label food effect sub-study",
    "page_start": 72,
    "page_end": 73,
    "track_label": "Food Effect Sub-Study",
    "column_count": 8,
    "row_count": 20,
    "header_row_count": 3,
    "activity_row_count": 17,
    "notes": "Printed in the protocol as Table 8. track: schedules a distinct sub-study population (food effect sub-study patients) on its own visit structure (FE Day 1 / FE Day 8 before Cycle 1), different columns from Table 7. Page 73 is the same printed Table 8 '(Continued)' under a reprinted header, not a separately numbered table, so it is extracted within this table. One label column (L=1); data columns 2-9."
  },
  "schedule_properties": [
    {
      "property_id": "prop-001",
      "table_id": "table-002",
      "row_position": 1,
      "property_name": "Period",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "epoch",
      "property_comment": "Unlabelled top header band naming the study periods: Screening (col 2), 14-Day Food Effect (merged cols 3-4), Cycle1 (merged cols 5-7), Subsequent Cycles (col 8), Treatment Discontinuation (within 7 days of last dose) (col 9). The Screening, 14-Day Food Effect, Subsequent Cycles and Treatment Discontinuation cells span header rows 1-2 vertically. Name synthesised; typed epoch because the values are study phases.",
      "hierarchical_level": 1,
      "parent_property_id": null,
      "child_property_ids": [
        "prop-002"
      ],
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "property_id": "prop-002",
      "table_id": "table-002",
      "row_position": 2,
      "property_name": "Cycle",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "cycle",
      "property_comment": "Unlabelled second header band subdividing the Cycle1 period: C1 (merged cols 5-6) and C2 (col 7). Other columns are empty here because their row-1 cells span down into this row. Name synthesised; typed cycle from the C1/C2 values.",
      "hierarchical_level": 2,
      "parent_property_id": "prop-001",
      "child_property_ids": [
        "prop-003"
      ],
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "property_id": "prop-003",
      "table_id": "table-002",
      "row_position": 3,
      "property_name": "Day",
      "property_name_source": {
        "row_position": 3,
        "column_position": 1,
        "cell_value": "Day"
      },
      "property_type": "study_day",
      "property_comment": "Study day: -28 to -1 (screening), FE 1 and FE 8 (food-effect days), Days 1 and 15 of Cycle 1, Day 1 of Cycle 2, 'Cycle n, Day 1' for subsequent cycles; discontinuation column blank.",
      "hierarchical_level": 3,
      "parent_property_id": "prop-002",
      "child_property_ids": [],
      "annotation_markers": "",
      "linked_annotation_ids": []
    }
  ],
  "schedule_columns": [
    {
      "column_id": "col-002",
      "table_id": "table-002",
      "column_position": 2,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Screening",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "-28 to -1",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Screening / -28 to -1",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-003",
      "table_id": "table-002",
      "column_position": 3,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "14-Day Food Effect",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "FE 1",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "14-Day Food Effect / FE 1",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-004",
      "table_id": "table-002",
      "column_position": 4,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "14-Day Food Effect",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "FE 8",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "14-Day Food Effect / FE 8",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-005",
      "table_id": "table-002",
      "column_position": 5,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Cycle",
          "is_merged": true,
          "annotation_markers": "1"
        },
        {
          "property_id": "prop-002",
          "value": "C1",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "1",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Cycle / C1 / 1",
      "linked_annotation_ids": [
        "annot-001"
      ]
    },
    {
      "column_id": "col-006",
      "table_id": "table-002",
      "column_position": 6,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Cycle",
          "is_merged": true,
          "annotation_markers": "1"
        },
        {
          "property_id": "prop-002",
          "value": "C1",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "15",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Cycle / C1 / 15",
      "linked_annotation_ids": [
        "annot-001"
      ]
    },
    {
      "column_id": "col-007",
      "table_id": "table-002",
      "column_position": 7,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Cycle",
          "is_merged": true,
          "annotation_markers": "1"
        },
        {
          "property_id": "prop-002",
          "value": "C2",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "1",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Cycle / C2 / 1",
      "linked_annotation_ids": [
        "annot-001"
      ]
    },
    {
      "column_id": "col-008",
      "table_id": "table-002",
      "column_position": 8,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Subsequent Cycles",
          "is_merged": false,
          "annotation_markers": "2"
        },
        {
          "property_id": "prop-002",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "Cycle n, Day 1",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Subsequent Cycles / Cycle n, Day 1",
      "linked_annotation_ids": [
        "annot-002"
      ]
    },
    {
      "column_id": "col-009",
      "table_id": "table-002",
      "column_position": 9,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Treatment Discontinuation (within 7 days of last dose)",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Treatment Discontinuation (within 7 days of last dose)",
      "linked_annotation_ids": []
    }
  ],
  "activities": [
    {
      "activity_id": "act-001",
      "table_id": "table-002",
      "row_position": 4,
      "activity_name": "Informed Consent",
      "activity_name_source": {
        "cell_text": "Informed Consent",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-002",
      "table_id": "table-002",
      "row_position": 5,
      "activity_name": "Demographics",
      "activity_name_source": {
        "cell_text": "Demographics",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-003",
      "table_id": "table-002",
      "row_position": 6,
      "activity_name": "Medical, cancer, surgical, medication history",
      "activity_name_source": {
        "cell_text": "Medical, cancer, surgical, medication history",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-004",
      "table_id": "table-002",
      "row_position": 7,
      "activity_name": "Pregnancy test",
      "activity_name_source": {
        "cell_text": "Pregnancy test",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-005",
      "table_id": "table-002",
      "row_position": 8,
      "activity_name": "Randomization",
      "activity_name_source": {
        "cell_text": "Randomization",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-006",
      "table_id": "table-002",
      "row_position": 9,
      "activity_name": "Study treatment dispensed/collected",
      "activity_name_source": {
        "cell_text": "Study treatment dispensed/collected",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-007",
      "table_id": "table-002",
      "row_position": 10,
      "activity_name": "Consumption of high fat meal, as applicable",
      "activity_name_source": {
        "cell_text": "Consumption of high fat meal, as applicable",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "table_id": "table-002",
      "row_position": 11,
      "activity_name": "Physical examination",
      "activity_name_source": {
        "cell_text": "Physical examination",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "table_id": "table-002",
      "row_position": 12,
      "activity_name": "Vital signs, height, weight",
      "activity_name_source": {
        "cell_text": "Vital signs, height⁷, weight",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "7",
      "linked_annotation_ids": [
        "annot-007"
      ]
    },
    {
      "activity_id": "act-010",
      "table_id": "table-002",
      "row_position": 13,
      "activity_name": "ECOG performance status",
      "activity_name_source": {
        "cell_text": "ECOG performance status",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "table_id": "table-002",
      "row_position": 14,
      "activity_name": "Hematology/serum chemistry",
      "activity_name_source": {
        "cell_text": "Hematology/serum chemistry",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-012",
      "table_id": "table-002",
      "row_position": 15,
      "activity_name": "Urinalysis",
      "activity_name_source": {
        "cell_text": "Urinalysis⁸",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "8",
      "linked_annotation_ids": [
        "annot-008"
      ]
    },
    {
      "activity_id": "act-013",
      "table_id": "table-002",
      "row_position": 16,
      "activity_name": "12-lead ECG",
      "activity_name_source": {
        "cell_text": "12-lead ECG⁹",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "9",
      "linked_annotation_ids": [
        "annot-009"
      ]
    },
    {
      "activity_id": "act-014",
      "table_id": "table-002",
      "row_position": 17,
      "activity_name": "Blood sample for PK",
      "activity_name_source": {
        "cell_text": "Blood sample for PK¹¹",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "11",
      "linked_annotation_ids": [
        "annot-011"
      ]
    },
    {
      "activity_id": "act-015",
      "table_id": "table-002",
      "row_position": 18,
      "activity_name": "Adverse event monitoring",
      "activity_name_source": {
        "cell_text": "Adverse event monitoring",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "table_id": "table-002",
      "row_position": 19,
      "activity_name": "Concomitant medications",
      "activity_name_source": {
        "cell_text": "Concomitant medications",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-017",
      "table_id": "table-002",
      "row_position": 20,
      "activity_name": "Bone marrow aspirate and biopsy",
      "activity_name_source": {
        "cell_text": "Bone marrow aspirate and biopsy",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "hierarchy_level": 0,
      "is_section_header": false,
      "parent_activity_id": null,
      "child_activity_ids": [],
      "has_schedule_data": true,
      "annotation_markers": "",
      "linked_annotation_ids": []
    }
  ],
  "activity_schedule": [
    {
      "activity_id": "act-001",
      "column_id": "col-002",
      "row_position": 4,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-002",
      "column_id": "col-002",
      "row_position": 5,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-003",
      "column_id": "col-002",
      "row_position": 6,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-004",
      "column_id": "col-002",
      "row_position": 7,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "3",
      "linked_annotation_ids": [
        "annot-003"
      ]
    },
    {
      "activity_id": "act-004",
      "column_id": "col-005",
      "row_position": 7,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "3",
      "linked_annotation_ids": [
        "annot-003"
      ]
    },
    {
      "activity_id": "act-005",
      "column_id": "col-002",
      "row_position": 8,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "4",
      "linked_annotation_ids": [
        "annot-004"
      ]
    },
    {
      "activity_id": "act-006",
      "column_id": "col-003",
      "row_position": 9,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "5",
      "linked_annotation_ids": [
        "annot-005"
      ]
    },
    {
      "activity_id": "act-006",
      "column_id": "col-004",
      "row_position": 9,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "5",
      "linked_annotation_ids": [
        "annot-005"
      ]
    },
    {
      "activity_id": "act-006",
      "column_id": "col-005",
      "row_position": 9,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-006",
      "column_id": "col-007",
      "row_position": 9,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-006",
      "column_id": "col-008",
      "row_position": 9,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-006",
      "column_id": "col-009",
      "row_position": 9,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "6",
      "linked_annotation_ids": [
        "annot-006"
      ]
    },
    {
      "activity_id": "act-007",
      "column_id": "col-003",
      "row_position": 10,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-007",
      "column_id": "col-004",
      "row_position": 10,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-002",
      "row_position": 11,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-003",
      "row_position": 11,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-005",
      "row_position": 11,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-006",
      "row_position": 11,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-007",
      "row_position": 11,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-008",
      "row_position": 11,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-008",
      "column_id": "col-009",
      "row_position": 11,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-002",
      "row_position": 12,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-003",
      "row_position": 12,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-004",
      "row_position": 12,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-005",
      "row_position": 12,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-006",
      "row_position": 12,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-007",
      "row_position": 12,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-008",
      "row_position": 12,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
      "column_id": "col-009",
      "row_position": 12,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-002",
      "row_position": 13,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-003",
      "row_position": 13,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-004",
      "row_position": 13,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-005",
      "row_position": 13,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-007",
      "row_position": 13,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-008",
      "row_position": 13,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-010",
      "column_id": "col-009",
      "row_position": 13,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-002",
      "row_position": 14,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-003",
      "row_position": 14,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-004",
      "row_position": 14,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-005",
      "row_position": 14,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-006",
      "row_position": 14,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-007",
      "row_position": 14,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-008",
      "row_position": 14,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-011",
      "column_id": "col-009",
      "row_position": 14,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-012",
      "column_id": "col-002",
      "row_position": 15,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-013",
      "column_id": "col-002",
      "row_position": 16,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-013",
      "column_id": "col-003",
      "row_position": 16,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "10",
      "linked_annotation_ids": [
        "annot-010"
      ]
    },
    {
      "activity_id": "act-013",
      "column_id": "col-004",
      "row_position": 16,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "10",
      "linked_annotation_ids": [
        "annot-010"
      ]
    },
    {
      "activity_id": "act-013",
      "column_id": "col-005",
      "row_position": 16,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-013",
      "column_id": "col-007",
      "row_position": 16,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-013",
      "column_id": "col-009",
      "row_position": 16,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
      "column_id": "col-003",
      "row_position": 17,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
      "column_id": "col-004",
      "row_position": 17,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
      "column_id": "col-005",
      "row_position": 17,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
      "column_id": "col-007",
      "row_position": 17,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
      "column_id": "col-008",
      "row_position": 17,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-002",
      "row_position": 18,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-003",
      "row_position": 18,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-004",
      "row_position": 18,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-005",
      "row_position": 18,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-006",
      "row_position": 18,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-007",
      "row_position": 18,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-008",
      "row_position": 18,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
      "column_id": "col-009",
      "row_position": 18,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "14",
      "linked_annotation_ids": [
        "annot-012"
      ]
    },
    {
      "activity_id": "act-016",
      "column_id": "col-002",
      "row_position": 19,
      "column_position": 2,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-003",
      "row_position": 19,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-004",
      "row_position": 19,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-005",
      "row_position": 19,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-006",
      "row_position": 19,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-007",
      "row_position": 19,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-008",
      "row_position": 19,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-016",
      "column_id": "col-009",
      "row_position": 19,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-017",
      "column_id": "col-003",
      "row_position": 20,
      "column_position": 3,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-004",
      "row_position": 20,
      "column_position": 4,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-005",
      "row_position": 20,
      "column_position": 5,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-006",
      "row_position": 20,
      "column_position": 6,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-007",
      "row_position": 20,
      "column_position": 7,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-008",
      "row_position": 20,
      "column_position": 8,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    },
    {
      "activity_id": "act-017",
      "column_id": "col-009",
      "row_position": 20,
      "column_position": 9,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "3:9",
      "annotation_markers": "15",
      "linked_annotation_ids": [
        "annot-013"
      ]
    }
  ],
  "annotations": [
    {
      "annotation_id": "annot-001",
      "table_id": "table-002",
      "annotation_marker": "1",
      "annotation_type": "footnote",
      "annotation_text": "Treatment cycles are 28 days long, visits on Day 1 of each cycle unless otherwise specified.",
      "annotation_scope": "column",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [
          "col-005",
          "col-006",
          "col-007"
        ],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 5
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 6
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 7
        }
      ]
    },
    {
      "annotation_id": "annot-002",
      "table_id": "table-002",
      "annotation_marker": "2",
      "annotation_type": "footnote",
      "annotation_text": "Visits continue every 4 weeks until study treatment discontinuation.",
      "annotation_scope": "column",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [
          "col-008"
        ],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 8
        }
      ]
    },
    {
      "annotation_id": "annot-003",
      "table_id": "table-002",
      "annotation_marker": "3",
      "annotation_type": "footnote",
      "annotation_text": "Negative serum pregnancy test required within 72 hours prior to study treatment for females of childbearing potential; repeated every 3 months for duration of study (ie, Cycle 4, Cycle 7, etc).",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-004",
            "column_id": "col-002"
          },
          {
            "activity_id": "act-004",
            "column_id": "col-005"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 7,
          "column_position": 2
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 7,
          "column_position": 5
        }
      ]
    },
    {
      "annotation_id": "annot-004",
      "table_id": "table-002",
      "annotation_marker": "4",
      "annotation_type": "footnote",
      "annotation_text": "Patients will be randomized in a crossover design within 72 hours prior to FE Day 1 (first single dose).",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-005",
            "column_id": "col-002"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 8,
          "column_position": 2
        }
      ]
    },
    {
      "annotation_id": "annot-005",
      "table_id": "table-002",
      "annotation_marker": "5",
      "annotation_type": "footnote",
      "annotation_text": "Patients receive a single oral dose of niraparib 300 mg on FE Days 1 and 8.",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-006",
            "column_id": "col-003"
          },
          {
            "activity_id": "act-006",
            "column_id": "col-004"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 9,
          "column_position": 3
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 9,
          "column_position": 4
        }
      ]
    },
    {
      "annotation_id": "annot-006",
      "table_id": "table-002",
      "annotation_marker": "6",
      "annotation_type": "footnote",
      "annotation_text": "No new capsules dispensed.",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-006",
            "column_id": "col-009"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 9,
          "column_position": 9
        }
      ]
    },
    {
      "annotation_id": "annot-007",
      "table_id": "table-002",
      "annotation_marker": "7",
      "annotation_type": "footnote",
      "annotation_text": "Height obtained at screening only.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-009"
        ],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 12
        }
      ]
    },
    {
      "annotation_id": "annot-008",
      "table_id": "table-002",
      "annotation_marker": "8",
      "annotation_type": "footnote",
      "annotation_text": "Urinalysis parameters must include: specific gravity, leukocyte esterase, nitrite, blood, protein, glucose, ketones, urobilinogen and bilirubin.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-012"
        ],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 15
        }
      ]
    },
    {
      "annotation_id": "annot-009",
      "table_id": "table-002",
      "annotation_marker": "9",
      "annotation_type": "footnote",
      "annotation_text": "12-lead ECG at Screening, Cycle 1/Day 1 (predose and 2 hours postdose), Cycle 2/Day 1 (predose and 2 hours postdose), and at treatment discontinuation. ECG monitoring is to be performed prior to PK blood draws.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-013"
        ],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 16
        }
      ]
    },
    {
      "annotation_id": "annot-010",
      "table_id": "table-002",
      "annotation_marker": "10",
      "annotation_type": "footnote",
      "annotation_text": "Triplicate ECG monitoring to coincide with PK on FE Days 1 and 8 at baseline (predose) and at 1, 1.5, 2, 3, 4, 6, and 8 hours post-dose. Triplicate ECGs should be performed between 2-5 minutes apart and should be performed prior to blood draws for PK.",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-013",
            "column_id": "col-003"
          },
          {
            "activity_id": "act-013",
            "column_id": "col-004"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 3
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 4
        }
      ]
    },
    {
      "annotation_id": "annot-011",
      "table_id": "table-002",
      "annotation_marker": "11",
      "annotation_type": "footnote",
      "annotation_text": "Blood samples for PK will be taken on FE Days 1 and 8 at baseline (within 30 minutes prior to dosing) and at 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, and 120 hours postdose. Additional blood samples will be collected predose and 2 hours postdose on Day 1 of Cycles 1 and 2 and predose only on Day 1 of Cycles 4 and 8. The exact time of the PK blood draw will be recorded and PK blood draws are to be completed after ECG monitoring.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-014"
        ],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 17
        }
      ]
    },
    {
      "annotation_id": "annot-012",
      "table_id": "table-002",
      "annotation_marker": "14",
      "annotation_type": "footnote",
      "annotation_text": "SAEs recorded up to 30 days after study treatment discontinuation.",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-015",
            "column_id": "col-009"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 18,
          "column_position": 9
        }
      ]
    },
    {
      "annotation_id": "annot-013",
      "table_id": "table-002",
      "annotation_marker": "15",
      "annotation_type": "footnote",
      "annotation_text": "For any suspected MDS/AML case reported while a patient is receiving treatment or being followed for post-treatment assessments, bone marrow aspirate and biopsy testing must be completed by a local hematologist. Testing completed as part of standard of care is sufficient as long as the methods are acceptable to the Sponsor’s Medical Monitor. The study site must receive a copy of the hematologist's report of aspirate/biopsy findings (which must include a classification according to WHO criteria²⁰) and other sample testing results related to MDS/AML.",
      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": [
          {
            "activity_id": "act-017",
            "column_id": "col-003"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-004"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-005"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-006"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-007"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-008"
          },
          {
            "activity_id": "act-017",
            "column_id": "col-009"
          }
        ]
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 3
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 4
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 5
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 6
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 7
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 8
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 20,
          "column_position": 9
        }
      ]
    },
    {
      "annotation_id": "annot-014",
      "table_id": "table-002",
      "annotation_marker": "n1",
      "annotation_type": "footnote",
      "annotation_text": "Note: Patients in food effect sub-study will receive a single oral dose of niraparib 300 mg on FE Days 1 and 8. Upon completion of the 14-day sub-study, patients will then start open-label treatment with daily niraparib (300 mg QD) on Day 1/Cycle 1 (approximately 2 weeks after start of food effect sub-study) and will be followed using the main study visit schedule for safety.",
      "annotation_scope": "table",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_property",
          "row_position": 1
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D3",
      "severity": "medium",
      "location": {
        "page": 72
      },
      "call_made": "Printed Table 8 is typed as a separate track ('Food Effect Sub-Study'): it schedules the food-effect sub-study patients on their own visits (FE Day 1, FE Day 8).",
      "alternative": "Type it main_soa, as an independent schedule table of its own, without a track label.",
      "report_section": "3.1"
    },
    {
      "id": "D4",
      "severity": "low",
      "location": {
        "page": 73,
        "row_position": 1,
        "annotation_marker": "12"
      },
      "call_made": "On the reprinted header of page 73 the footnotes on 'Cycle' and 'Subsequent Cycles' are renumbered 12 and 13; their text is identical to footnotes 1 and 2, so the reprinted header is de-duplicated and 12/13 are not emitted as separate notes.",
      "alternative": "Emit footnotes 12 and 13 as their own notes on the same header cells, in addition to 1 and 2.",
      "report_section": "3.4"
    },
    {
      "id": "D5",
      "severity": "high",
      "location": {
        "page": 73,
        "row_position": 1,
        "annotation_marker": "n1"
      },
      "call_made": "The full-width 'Note: Patients in food effect sub-study ...' row at the foot of the page-73 table is not an activity; it is kept as one footnote (synthesised marker n1) applying to the whole table, anchored on header row 1.",
      "alternative": "Bind the note to specific rows (e.g. study treatment dispensed/collected) or leave its scope unresolved.",
      "report_section": "3.3"
    }
  ]
}