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      "annotation_scope": "cell",
      "referenced_elements": {
        "property_ids": [],
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      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
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      "annotation_scope": "activity",
      "referenced_elements": {
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    {
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      "annotation_text": "Footnote not printed in the source (Table 9 prints only footnotes 1-3). Table 9 is the Extended-Visit-Cycle variant of the Main Study, this corresponds to Table 7 (Main Study) footnote 16: \"Patients will have a 12-lead ECG at Screening, Baseline (predose, within 30 minutes), 2 hours postdose on Day 1(within 30 minutes), Cycle 2/Day 1, (predose, 2 hours postdose, within 30 minutes) and upon study treatment discontinuation. Note that the ECG is to be completed prior to the PK blood draw.\" Mapping confirmed by clinical review (2026-08-15): §7.4.3 lists 12-lead ECG at study treatment discontinuation — the only ECG mark in this table; the screening/PK clauses of footnote 16 do not apply in extended cycles.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
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    },
    {
      "annotation_id": "annot-010",
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      "annotation_text": "Footnote not printed in the source (Table 9 prints only footnotes 1-3). Table 9 is the Extended-Visit-Cycle variant of the Main Study, so this most likely corresponds to Table 7 (Main Study) footnote 22: \"RECIST tumor assessment via CT or MRI scan of abdomen/pelvis and clinically indicated areas required at baseline, then after every 2 cycles (ie, 8 weeks with a window of ± 7 days from date of visit) through Cycle 14 (56 weeks), then after every 6 cycles (24 weeks with a window of ± 7 days) until study treatment discontinuation; at this point, a final follow-up set of imaging is required. PET/CT may be used according to RECIST guidelines. Cycle timing will not be delayed for treatment interruptions, and tumor assessment should occur according to this schedule regardless of whether study treatment is interrupted. If a patient discontinues treatment for clinical progression and does not meet the criteria specified in the protocol, scans and CA-125 testing should continue at the specified intervals until progression is confirmed or until the start of subsequent anticancer treatment.\" NOTE (clinical review 2026-08-15): §7.4.2 states RECIST \"after every 2 cycles through Cycle 14 and then after every 3 cycles\", which conflicts with footnote 22's post-Cycle-14 cadence of every 6 cycles (24 weeks) — a source-internal contradiction, left unresolved; hypothesis retained.",
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  "review_items": [
    {
      "id": "D6",
      "severity": "medium",
      "location": {
        "page": 78
      },
      "call_made": "Printed Table 9 (Main Study – Extended Visit Cycle) is typed as a separate track ('Extended Visit Cycle'): main-study patients in a later phase follow an alternative visit pattern (in-clinic extended cycle, telephone contact, local clinic / in-home nursing).",
      "alternative": "Type it main_soa as an independent schedule, or subsidiary to Table 7's 'Subsequent Cycles' column.",
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      "severity": "medium",
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          7,
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          12,
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      },
      "call_made": "Footnote markers 4-15 of printed Table 9 have no text in the excerpt; each is kept as a note saying the definition is not printed, with a clearly-labelled probable equivalent from Table 7 where one exists.",
      "alternative": "State only that the definition is not printed, with no Table 7 cross-reference.",
      "report_section": "4.3"
    }
  ]
}