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Text layer present; vector grid read from the 200-dpi raster (section 1d).", "model": "claude-opus-5-5" }, "table_metadata": { "table_number": 1, "table_type": "main_soa", "table_title": "Study Schedule, Protocol I3Y-MC-JPBL", "table_purpose": "Main study schedule: baseline, on-treatment cycles and postdiscontinuation follow-up", "page_start": 73, "page_end": 77, "notes": "Printed as one table whose rows run across pages 73-75 under a header reprinted on each page (header de-duplicated); pages 76-77 carry only the continued footnotes b-q ('(continued)' / '(concluded)' captions belong to the footnotes, not to new tables). Three leading label columns (Procedure Category, Procedure, Protocol Reference); header-row labels sit in column 3; data columns 4-11. Subtitle printed under the title: 'Perform procedure as indicated.' Protocol Reference column entries emitted as source_note annotations (pr markers numbered study-wide). 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Long-term follow-up begins the day after short-term follow-up is completed and continues until the patient’s death or overall study completion; the associated study procedures are performed approximately every 12 weeks (± 14 days) for the duration of this period.", "marker_locations": [ { "table_number": 1, "location_type": "schedule_cell", "row_position": 2, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 2, "column_position": 11 } ], "annotation_text_source": { "method": "visual_transcription", "note": "Text read from the text layer and checked against the 200-dpi render. Characters the text layer mangles were restored from the render: a Symbol-font private-use glyph U+F0B1 mapped to the ± sign (note a), and line-break hyphens that pdftotext dropped put back (note b: Day -1; note j: post-baseline)." } }, { "annotation_marker": "b", "annotation_type": "footnote", "annotation_text": "For patients with inoperable locally advanced breast cancer, MRI scan of the breast is performed locally at baseline (Day -28 to Day -1), between Day 1 and Day 7 of every second cycle beginning with Cycle 3 and continuing through Cycle 13, between Day 1 and Day 7 of every third cycle after Cycle 13, and within 14 days of clinical progression. For all patients, CT or MRI scan of the chest, abdomen, and pelvis is performed locally at baseline (Day -28 to Day -1), between Day 1 and Day 7 of every second cycle beginning with Cycle 3 and continuing through Cycle 13, between Day 1 and Day 7 of every third cycle after Cycle 13, and within 14 days of clinical progression. It is recommended that CT imaging of the abdomen and pelvis be performed with IV contrast whenever possible. If this is not feasible due to hypersensitivity or other conditions, then gadolinium-enhanced MRI is preferred. For patients with known serious allergic reactions to CT contrast material, a CT of the chest without contrast and gadolinium-enhanced MRI of the abdomen/pelvis are encouraged. For patients who discontinue study treatment without objectively measured progressive disease (PD), continue to evaluate tumor response approximately every 8 weeks for the first 12 months following randomization and thereafter approximately every 12 weeks by the same method used at baseline and throughout the study until the patient has objective disease progression or until study completion. After the patient has objective disease progression, radiologic tests are no longer required and the patient will continue with post-discontinuation follow-up until the patient’s death or overall study completion.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 21 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 4 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 21, "column_position": 11 } ], "annotation_text_source": { "method": "visual_transcription", "note": "Text read from the text layer and checked against the 200-dpi render. Characters the text layer mangles were restored from the render: a Symbol-font private-use glyph U+F0B1 mapped to the ± sign (note a), and line-break hyphens that pdftotext dropped put back (note b: Day -1; note j: post-baseline)." } }, { "annotation_marker": "c", "annotation_type": "footnote", "annotation_text": "Visible tumor (such as skin lesions) should be documented by photography and each photographic image of the tumor should include a ruler. For patients who discontinue study treatment without objectively measured progressive disease (PD), continue to evaluate tumor response approximately every 8 weeks for the first 12 months following randomization and thereafter approximately every 12 weeks by the same method used at baseline and throughout the study until the patient has objective disease progression or until study completion. After the patient has objective disease progression, tumor assessments are no longer required and the patient will continue with post-discontinuation follow-up until the patient’s death or overall study completion.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 20 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 4 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 20, "column_position": 11 } ] }, { "annotation_marker": "d", "annotation_type": "footnote", "annotation_text": "Survival information is collected at baseline and during both study treatment and postdiscontinuation follow-up. During Long-Term Follow-Up, survival information is collected approximately every 12 weeks for the duration of this period. Although preferable to collect during a clinic visit, survival information may be collected by contacting the patient or family directly (for example, via telephone). Long-Term Follow-up data collection may include anticancer therapies.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 24 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 24, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 24, "column_position": 11 } ] }, { "annotation_marker": "e", "annotation_type": "footnote", "annotation_text": "A local ECG (no replicates required) should be obtained at baseline (Day -14 to Day -1), 2 to 4 hours after the LY dose on Cycle 1 Day 1, upon arrival at site but prior to fulvestrant dose on Cycle 1 Day 15, 2 to 4 hours after the LY dose on Cycle 4 Day 1, and at the short-term follow-up visit.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 35 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 35, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 35, "column_position": 6 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 35, "column_position": 7 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 35, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 35, "column_position": 10 } ] }, { "annotation_marker": "f", "annotation_type": "footnote", "annotation_text": "Data on SAEs that occur before the end of trial will be stored in the collection database and the Lilly Safety System. During Long-Term Follow-Up, only SAEs that are related to study drugs or protocol procedures will be collected. All adverse events possibly related to study drugs or protocol procedures should be followed until they resolve, are no longer considered to be possibly related, become stable or return to baseline, the patient starts a new therapy, the patient expires, or the patient becomes lost to follow-up. The frequency of evaluation is determined according to the judgment of the investigator.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 25 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 6 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 7 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 25, "column_position": 11 } ] }, { "annotation_marker": "g", "annotation_type": "footnote", "annotation_text": "LY2835219 should be administered orally every 12 hours on Days 1 through 28 of each cycle; patients should not consume food beginning 1 hour before and ending 1 hour after taking LY2835219. Fulvestrant 500 mg should be administered intramuscularly into the buttocks slowly (1 to 2 minutes per injection) as two 250-mg injections, one in each buttock; however, for patients with moderate hepatic impairment (defined as Child-Pugh Class B), including any patient who develops moderate hepatic impairment during study treatment, fulvestrant 250 mg should be administered intramuscularly into the buttock slowly (1 to 2 minutes) as one 250-mg injection.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 38 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 6 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 7 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 38, "column_position": 11 }, { "table_number": 1, "location_type": "activity_name", "row_position": 39 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 6 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 7 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 39, "column_position": 11 } ] }, { "annotation_marker": "h", "annotation_type": "footnote", "annotation_text": "Formalin-fixed paraffin-embedded tumor tissue (either block or 15-20 unstained slides) should be requested at the time of randomization. However, if this sample is not available for a patient, it will not constitute a protocol deviation", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 36 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 36, "column_position": 6 } ] }, { "annotation_marker": "i", "annotation_type": "footnote", "annotation_text": "Bone scintigraphy is performed locally at baseline (Day -28 to Day -1) for all patients. If available, prior bone scintigraphy (obtained as part of routine clinical care) within 45 days before Day 1 of Cycle 1 is also acceptable. Bone scintigraphy should be repeated for all patients between Day 1 and Day 7 of every sixth cycle beginning with Cycle 7, when complete response is identified in target disease, or when progression in bone is suspected. Importantly, RECIST v1.1 emphasizes that bone scintigraphy is not adequate to measure bone lesions; however, bone scintigraphy can be used to confirm the presence or disappearance of bone lesions. For patients who discontinue study treatment without objectively measured progressive disease (PD), continue to evaluate tumor response approximately every 6 months until the patient has objective disease progression or until study completion. After the patient has objective disease progression, bone scintigraphy is no longer required and the patient will continue with post-discontinuation follow-up until the patient’s death or overall study completion.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 22 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 22, "column_position": 4 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 22, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 22, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 22, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 22, "column_position": 11 } ] }, { "annotation_marker": "j", "annotation_type": "footnote", "annotation_text": "One or more of these studies [X-ray, CT scan with bone windows, or MRI] is performed locally at baseline (Day -28 to Day -1), between Day 1 and Day 7 of every second cycle beginning with Cycle 3 and continuing through Cycle 13, between Day 1 and Day 7 of every third cycle after Cycle 13, and within 14 days of clinical progression only for patients with bone lesions identified by bone scintigraphy at baseline. For patients with new lesions identified by post-baseline bone scintigraphy, targeted assessment by X-ray, CT scan with bone windows, or MRI will be performed to confirm findings. For patients who discontinue study treatment without objectively measured progressive disease (PD), continue to evaluate tumor response approximately every 8 weeks for the first 12 months following randomization and thereafter approximately every 12 weeks by the same method used at baseline and throughout the study until the patient has objective disease progression or until study completion. After the patient has objective disease progression, radiologic tests are no longer required and the patient will continue with post-discontinuation follow-up until the patient’s death or overall study completion.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 23 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 4 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 23, "column_position": 11 } ], "annotation_text_source": { "method": "visual_transcription", "note": "Text read from the text layer and checked against the 200-dpi render. Characters the text layer mangles were restored from the render: a Symbol-font private-use glyph U+F0B1 mapped to the ± sign (note a), and line-break hyphens that pdftotext dropped put back (note b: Day -1; note j: post-baseline)." } }, { "annotation_marker": "k", "annotation_type": "footnote", "annotation_text": "mBPI-sf, EORTC QLQ-C30, EORTC QLQ-BR23 and EQ-5D 5L should be administered at baseline (Day -14 to Day -1), Cycle 2 Day 1, and then on Day 1 of every second cycle beginning with Cycle 3 and continuing through Cycle 13, on Day 1 of every third cycle after Cycle 13, and at Short-Term Follow-Up. Patients should complete these assessments before extensive interaction with site staff.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 41 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 41, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 41, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 41, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 41, "column_position": 10 } ] }, { "annotation_marker": "l", "annotation_type": "footnote", "annotation_text": "Skeletal-Related Events include pathological fracture, spinal cord compression, radiation to bone, and surgery to bone.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 42 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 42, "column_position": 5 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 42, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 42, "column_position": 9 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 42, "column_position": 10 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 42, "column_position": 11 } ] }, { "annotation_marker": "m", "annotation_type": "source_note", "annotation_text": "See Pharmacokinetic Sampling Schedule (Attachment 7).", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 32 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 32, "column_position": 6 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 32, "column_position": 7 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 32, "column_position": 8 } ] }, { "annotation_marker": "n", "annotation_type": "footnote", "annotation_text": "FSH and estradiol levels are required only for women age <60 years and amenorrheic for at least 12 months.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 30 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 30, "column_position": 5 } ] }, { "annotation_marker": "o", "annotation_type": "footnote", "annotation_text": "A serum pregnancy test is required only for patients receiving ovarian suppression with a GnRH agonist.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 31 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 31, "column_position": 5 } ] }, { "annotation_marker": "p", "annotation_type": "footnote", "annotation_text": "For Cycle 2 and beyond, the start of a cycle may be delayed up to 7 days for logistical reasons and up to 14 days to allow sufficient time for recovery from toxicity possibly related to a study drug. Refer to Section 9.4.1.1.2.", "marker_locations": [ { "table_number": 1, "location_type": "schedule_cell", "row_position": 5, "column_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 5, "column_position": 9 } ] }, { "annotation_marker": "q", "annotation_type": "footnote", "annotation_text": "Informed Consent Form is signed within 28 days prior to randomization of study drug and prior to performance of any protocol-specific tests/procedures.", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 8 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 8, "column_position": 4 }, { "table_number": 1, "location_type": "schedule_cell", "row_position": 8, "column_position": 5 } ] }, { "annotation_marker": "pr1", "annotation_type": "source_note", "annotation_text": "Section 8.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 8, "method": "synthesized" } ] }, { "annotation_marker": "pr2", "annotation_type": "source_note", "annotation_text": "Section 7", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 9, "method": "synthesized" } ] }, { "annotation_marker": "pr3", "annotation_type": "source_note", "annotation_text": "Section 12.2.3", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 12, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 13, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 15, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 16, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 17, "method": "synthesized" } ] }, { "annotation_marker": "pr4", "annotation_type": "source_note", "annotation_text": "Section 7.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 18, "method": "synthesized" } ] }, { "annotation_marker": "pr5", "annotation_type": "source_note", "annotation_text": "Attachment 4", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 18, "method": "synthesized" } ] }, { "annotation_marker": "pr6", "annotation_type": "source_note", "annotation_text": "Section 10.1.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 20, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 21, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 22, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 23, "method": "synthesized" } ] }, { "annotation_marker": "pr7", "annotation_type": "source_note", "annotation_text": "Attachment 5", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 21, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 22, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 23, "method": "synthesized" } ] }, { "annotation_marker": "pr8", "annotation_type": "source_note", "annotation_text": "Section 10.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 24, "method": "synthesized" } ] }, { "annotation_marker": "pr9", "annotation_type": "source_note", "annotation_text": "Section 10.3", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 25, "method": "synthesized" } ] }, { "annotation_marker": "pr10", "annotation_type": "source_note", "annotation_text": "Section 9.6", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 26, "method": "synthesized" } ] }, { "annotation_marker": "pr11", "annotation_type": "source_note", "annotation_text": "Attachment 2", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 28, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 29, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 30, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 31, "method": "synthesized" } ] }, { "annotation_marker": "pr12", "annotation_type": "source_note", "annotation_text": "Attachment 7", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 32, "method": "synthesized" } ] }, { "annotation_marker": "pr13", "annotation_type": "source_note", "annotation_text": "Section 10.4.2.2", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 33, "method": "synthesized" } ] }, { "annotation_marker": "pr14", "annotation_type": "source_note", "annotation_text": "Section 10.4.2.3", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 34, "method": "synthesized" } ] }, { "annotation_marker": "pr15", "annotation_type": "source_note", "annotation_text": "Section 10.3.2.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 35, "method": "synthesized" } ] }, { "annotation_marker": "pr16", "annotation_type": "source_note", "annotation_text": "Section 10.4.2.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 36, "method": "synthesized" } ] }, { "annotation_marker": "pr17", "annotation_type": "source_note", "annotation_text": "Section 9.1", "marker_locations": [ { "table_number": 1, "location_type": "activity_name", "row_position": 38, "method": "synthesized" }, { "table_number": 1, "location_type": "activity_name", "row_position": 39, 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Outcomes) is emitted as its own mark-free level-0 grouping row placed just above the procedures it spans; those procedures are level 1. These grouping rows are not separate printed rows.", "alternative": "Treat the category column only as a label column: no grouping rows, all procedures level 0 (flat), with the category lost or kept only in cell_text.", "report_section": "3.2" }, { "id": "D2", "severity": "high", "location": { "page": 75, "row_positions": [ 38, 39 ] }, "call_made": "The Fulvestrant and LY2835219 dosing text cells are spread across columns 6-11 (every on-treatment and follow-up column), because the ruled merged cell runs to the right edge of the table.", "alternative": "Limit the dosing text to the on-treatment columns 6-9, reading the cell as only drawn wide for layout, since no study drug is given during postdiscontinuation follow-up.", "report_section": "3.3" }, { "id": "D3", "severity": "low", "location": { "page": 73, "row_position": 4 }, "call_made": "The 'Approximate Duration (days)' header row is kept with no hierarchy level (null), because it does not tell any two columns apart. 'Relative day within a cycle' is level 4.", "alternative": "Give Duration level 4 and Relative day level 5, following the printed row order.", "report_section": "3.4" }, { "id": "D4", "severity": "low", "location": { "page": 73, "row_position": 2 }, "call_made": "The 'Cycle' row is typed as cycle, even though its last two cells are 'Short-Term Follow-Up' and 'Long-Term Follow-Up', which are follow-up periods and not cycles.", "alternative": "Type the row 'other', or treat the follow-up cells as period labels.", "report_section": "3.4" }, { "id": "D5", "severity": "low", "location": { "page": 73, "row_position": 1 }, "call_made": "The subtitle 'Perform procedure as indicated.' under the table title is kept only in table_metadata.notes and is not emitted as an annotation.", "alternative": "Emit it as a table-scope footnote with a synthesised marker on header row 1.", "report_section": "3.5" } ] }