{
  "schema_name": "soa-table-extraction",
  "schema_version": "1.0",
  "extraction_metadata": {
    "extracted_at": "2026-09-27T12:37:09+00:00",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT03283098_soa.pdf",
      "document_type": "protocol",
      "document_version": "Protocol Number 20140197 (AMG 416)",
      "document_date": "25 May 2018"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Text-layer PDF with vector rule lines; marks verified by pdftotext -bbox column binning against header day-label x-centres and diffed against a visual read (no disagreements). 1 leading label column(s); first data column position 2.",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_number": 1,
    "table_type": "main_soa",
    "table_title": "Table 1a. Schedule of Non-laboratory Assessments",
    "table_purpose": "Main schedule: non-laboratory assessments across screening, dosing (Days 1-27) and follow-up to Day 55 (EOS)",
    "page_start": 32,
    "page_end": 33,
    "notes": "Printed under the overall caption 'Table 1. Schedule of Assessments'; 1a, 1b and 1c share one column structure (Screening, Day -2 ... Day 55). 1a is the anchor grid (main_soa). Page 33 carries only the abbreviation line and footnotes a-i (no activity rows)."
  },
  "schedule_properties": [
    {
      "table_number": 1,
      "row_position": 1,
      "property_name": "Study Visit (Day)",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "other",
      "hierarchical_level": null,
      "structure_method": "inferred_from_layout",
      "property_comment": "Banner row: the caption 'Study Visit (Day)' printed once in a cell merged across all data columns (2-21). It names the row below and does not by itself distinguish one column from another, so hierarchical_level is null; label cell empty, name taken from the banner text."
    },
    {
      "table_number": 1,
      "row_position": 2,
      "property_name": "Study Day",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "study_day",
      "hierarchical_level": 1,
      "property_comment": "Study visit days (Screening, Day -2, 1 ... 55); '(HD)' printed inside the same cell marks hemodialysis days and is kept literally. Classified study_day because the values are protocol day numbers per the banner 'Study Visit (Day)'; the Screening column is the only non-numeric day. Label cell holds the activity-column heading ('Assessment'), so the property name is synthesized."
    }
  ],
  "schedule_grid": [
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 2,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 2,
      "cell_value": "Screening"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 3,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 3,
      "cell_value": "-2"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 4,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 4,
      "cell_value": "1 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 5,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 5,
      "cell_value": "2"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 6,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 6,
      "cell_value": "3 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 7,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 7,
      "cell_value": "6 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 8,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 8,
      "cell_value": "8 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 9,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 9,
      "cell_value": "10 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 10,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 10,
      "cell_value": "13 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 11,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 11,
      "cell_value": "15 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 12,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 12,
      "cell_value": "17 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 13,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 13,
      "cell_value": "20 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 14,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 14,
      "cell_value": "22 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 15,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 15,
      "cell_value": "24 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 16,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 16,
      "cell_value": "27 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 17,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 17,
      "cell_value": "28"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 18,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 18,
      "cell_value": "29/ET (HD)",
      "annotation_markers": "a,h"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 19,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 19,
      "cell_value": "34 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 20,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 20,
      "cell_value": "41 (HD)"
    },
    {
      "table_number": 1,
      "row_position": 1,
      "column_position": 21,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 1,
      "row_position": 2,
      "column_position": 21,
      "cell_value": "55 (HD)"
    }
  ],
  "activities": [
    {
      "table_number": 1,
      "row_position": 3,
      "source_page": 32,
      "activity_name": "Informed consent",
      "activity_name_source": {
        "cell_text": "Informed consent",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      }
    },
    {
      "table_number": 1,
      "row_position": 4,
      "source_page": 32,
      "activity_name": "Eligibility",
      "activity_name_source": {
        "cell_text": "Eligibility",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      }
    },
    {
      "table_number": 1,
      "row_position": 5,
      "source_page": 32,
      "activity_name": "Medical and surgical history",
      "activity_name_source": {
        "cell_text": "Medical and surgical history",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      }
    },
    {
      "table_number": 1,
      "row_position": 6,
      "source_page": 32,
      "activity_name": "Demographics",
      "activity_name_source": {
        "cell_text": "Demographicsi",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "i"
    },
    {
      "table_number": 1,
      "row_position": 7,
      "source_page": 32,
      "activity_name": "Prior medications",
      "activity_name_source": {
        "cell_text": "Prior medications",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      }
    },
    {
      "table_number": 1,
      "row_position": 8,
      "source_page": 32,
      "activity_name": "Body Height",
      "activity_name_source": {
        "cell_text": "Body Heightb",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "b"
    },
    {
      "table_number": 1,
      "row_position": 9,
      "source_page": 32,
      "activity_name": "Body Weight",
      "activity_name_source": {
        "cell_text": "Body Weightb",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "b"
    },
    {
      "table_number": 1,
      "row_position": 10,
      "source_page": 32,
      "activity_name": "Physical exam",
      "activity_name_source": {
        "cell_text": "Physical examb",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "b"
    },
    {
      "table_number": 1,
      "row_position": 11,
      "source_page": 32,
      "activity_name": "Hemodialysis symptoms",
      "activity_name_source": {
        "cell_text": "Hemodialysis symptomsc",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "c"
    },
    {
      "table_number": 1,
      "row_position": 12,
      "source_page": 32,
      "activity_name": "Investigational product administration",
      "activity_name_source": {
        "cell_text": "Investigational product\nadministrationd",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "d"
    },
    {
      "table_number": 1,
      "row_position": 13,
      "source_page": 32,
      "activity_name": "Vital Signs (BP, HR, RR, TEMP)",
      "activity_name_source": {
        "cell_text": " Vital Signs (BP, HR, RR,\nTEMP)e",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "e"
    },
    {
      "table_number": 1,
      "row_position": 14,
      "source_page": 32,
      "activity_name": "12-lead electrocardiogram",
      "activity_name_source": {
        "cell_text": "12-lead electrocardiogramf",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "f"
    },
    {
      "table_number": 1,
      "row_position": 15,
      "source_page": 32,
      "activity_name": "Adverse Event Monitoring",
      "activity_name_source": {
        "cell_text": "Adverse Event Monitoringg",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      },
      "annotation_markers": "g"
    },
    {
      "table_number": 1,
      "row_position": 16,
      "source_page": 32,
      "activity_name": "Concomitant Medications",
      "activity_name_source": {
        "cell_text": "Concomitant Medications",
        "indentation_level": 0,
        "indentation_method": "assumed_flat"
      }
    }
  ],
  "activity_schedule": [
    {
      "table_number": 1,
      "row_position": 3,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 4,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 5,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 6,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 7,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 7,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 8,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 9,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 9,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 9,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 9,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 9,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 10,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 10,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 10,
      "column_position": 11,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 10,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 10,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 11,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 6,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 7,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 8,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 10,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 11,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 13,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 14,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 12,
      "column_position": 16,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 6,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 7,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 8,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 10,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 11,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 13,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 14,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 16,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 19,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 20,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 13,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 14,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 14,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 14,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 14,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 6,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 7,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 8,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 10,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 11,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 13,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 14,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 16,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 19,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 20,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 15,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 2,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 3,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 4,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 6,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 7,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 8,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 10,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 11,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 13,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 14,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 16,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 19,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 20,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 1,
      "row_position": 16,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    }
  ],
  "annotations": [
    {
      "annotation_marker": "a",
      "annotation_type": "footnote",
      "annotation_text": "If a treated subject withdraws before completion of dosing, the investigator will make every effort to perform Day 29 assessments as close to 2 days after the last dose of investigational product as possible.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "schedule_property",
          "row_position": 2,
          "column_position": 18
        }
      ]
    },
    {
      "annotation_marker": "b",
      "annotation_type": "footnote",
      "annotation_text": "A physical examination will be performed at screening. Abbreviated physical examinations will be performed on day 1 (unless day 1 occurred more than 2 weeks after screening physical examination), Days 15, 29 and 55. Height will be captured once at screening. Weight will be recorded before dialysis.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 8
        },
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 9
        },
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 10
        }
      ]
    },
    {
      "annotation_marker": "c",
      "annotation_type": "footnote",
      "annotation_text": "Common symptoms associated with hemodialysis will be captured at screening. Any worsening of hemodialysis symptoms will be reported as an adverse event.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 11
        }
      ]
    },
    {
      "annotation_marker": "d",
      "annotation_type": "footnote",
      "annotation_text": "Investigational product will be administered by intravenous (IV) injection over approximately 30 seconds into the venous line with dialysis rinse back at the end of the dialysis session.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 12
        }
      ]
    },
    {
      "annotation_marker": "e",
      "annotation_type": "footnote",
      "annotation_text": "Subjects will remain seated for at least 10 minutes prior to measurement of predialysis heart rate and blood pressure. Vital signs will include blood pressure, heart rate, respiratory rate, and oral or ear temperature. Vital signs will be obtained pre-dialysis treatments on scheduled dialysis days, and at ET and on Day 55 (EOS).",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 13
        }
      ]
    },
    {
      "annotation_marker": "f",
      "annotation_type": "footnote",
      "annotation_text": "Subjects will remain supine for at least 5 minutes prior to recording 12-lead electrocardiogram (ECG). Screening 12-lead ECG will be recorded prior to hemodialysis. The Day -2 12-lead ECG will be recorded within 4 hours after hemodialysis rinse back. After the last dose of investigational product on Day 27, 12-lead ECGs will be recorded between 18 and 30 hours (recorded on day 28) post-dose.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 14
        }
      ]
    },
    {
      "annotation_marker": "g",
      "annotation_type": "footnote",
      "annotation_text": "Adverse events will be monitored and recorded from the dose of investigational product (AMG 416) or placebo. Serious adverse events will be monitored and recorded from the time of informed consent through Day 55.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 15
        }
      ]
    },
    {
      "annotation_marker": "h",
      "annotation_type": "footnote",
      "annotation_text": "After Day 28, hemodialysis will continue on study days 29, 31, 34, 36, 38, 41, 43, 45, 48, 50, 52 and 55; data collection and study procedures will only occur on hemodialysis days 29, 34, 41, and 55(EOS).",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "schedule_property",
          "row_position": 2,
          "column_position": 18
        }
      ]
    },
    {
      "annotation_marker": "i",
      "annotation_type": "footnote",
      "annotation_text": "Demographic information collected at screening includes sex, age, race, and ethnicity.",
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 6
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D1",
      "severity": "low",
      "location": {
        "page": 32,
        "row_position": 2
      },
      "call_made": "The '(HD)' printed under a day number is kept inside that day's header value (e.g. '3 (HD)'), as one header row, in all three tables.",
      "alternative": "Split '(HD)' into a separate header row (modality: hemodialysis day) so day number and HD flag are separate properties.",
      "report_section": "2.1"
    }
  ]
}