{
  "schema_name": "soa-table-extraction",
  "schema_version": "1.0",
  "extraction_metadata": {
    "extracted_at": "2026-09-27T12:37:09+00:00",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT03283098_soa.pdf",
      "document_type": "protocol",
      "document_version": "Protocol Number 20140197 (AMG 416)",
      "document_date": "25 May 2018"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Text-layer PDF with vector rule lines; marks verified by pdftotext -bbox column binning against header day-label x-centres and diffed against a visual read (no disagreements). 2 leading label column(s); first data column position 3.",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_number": 3,
    "table_type": "domain",
    "table_title": "Table 1c. Schedule of Pharmacokinetic Assessments",
    "table_purpose": "Pharmacokinetic sampling by time relative to hemodialysis / study drug administration, on the shared Screening-Day 55 timeline",
    "page_start": 36,
    "page_end": 36,
    "notes": "Classified domain rather than subsidiary: it prints exactly the same day columns as Tables 1a/1b (not a finer column structure) for the same participants, and its finer timing lives in the rows (Time label column: Pre HD, SDA + 10/30/60/90 min, SDA + 18 to 30 hr). Two leading label columns (Time, Assessment); data columns 3-22. The Time value is folded into activity_name to keep the six 'PK' rows distinct. 'Central Laboratory' band spanning the data columns is taken as a level-0 section header. Marker 'a' on the 29/ET header has no footnote printed with this table."
  },
  "schedule_properties": [
    {
      "table_number": 3,
      "row_position": 1,
      "property_name": "Study Visit (Day)",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "other",
      "hierarchical_level": null,
      "structure_method": "inferred_from_layout",
      "property_comment": "Banner row: the caption 'Study Visit (Day)' printed once in a cell merged across all data columns (3-22). It names the row below and does not by itself distinguish one column from another, so hierarchical_level is null; label cell empty, name taken from the banner text."
    },
    {
      "table_number": 3,
      "row_position": 2,
      "property_name": "Study Day",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "study_day",
      "hierarchical_level": 1,
      "property_comment": "Study visit days (Screening, Day -2, 1 ... 55); '(HD)' printed inside the same cell marks hemodialysis days and is kept literally. Classified study_day because the values are protocol day numbers per the banner 'Study Visit (Day)'; the Screening column is the only non-numeric day. Label cell holds the activity-column heading ('Assessment'), so the property name is synthesized."
    }
  ],
  "schedule_grid": [
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 3,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 3,
      "cell_value": "Screening"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 4,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 4,
      "cell_value": "-2"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 5,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 5,
      "cell_value": "1 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 6,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 6,
      "cell_value": "2"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 7,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 7,
      "cell_value": "3 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 8,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 8,
      "cell_value": "6 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 9,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 9,
      "cell_value": "8 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 10,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 10,
      "cell_value": "10 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 11,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 11,
      "cell_value": "13 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 12,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 12,
      "cell_value": "15 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 13,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 13,
      "cell_value": "17 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 14,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 14,
      "cell_value": "20 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 15,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 15,
      "cell_value": "22 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 16,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 16,
      "cell_value": "24 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 17,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 17,
      "cell_value": "27 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 18,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 18,
      "cell_value": "28"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 19,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 19,
      "cell_value": "29/ET (HD)",
      "annotation_markers": "a"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 20,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 20,
      "cell_value": "34 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 21,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 21,
      "cell_value": "41 (HD)"
    },
    {
      "table_number": 3,
      "row_position": 1,
      "column_position": 22,
      "cell_value": "Study Visit (Day)",
      "is_merged_cell": true,
      "merged_cell_range": "3:22"
    },
    {
      "table_number": 3,
      "row_position": 2,
      "column_position": 22,
      "cell_value": "55 (HD)"
    }
  ],
  "activities": [
    {
      "table_number": 3,
      "row_position": 3,
      "source_page": 36,
      "activity_name": "Central Laboratory",
      "activity_name_source": {
        "cell_text": "Central Laboratory",
        "indentation_level": 0,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 4,
      "source_page": 36,
      "activity_name": "PK (Pre HD)",
      "activity_name_source": {
        "cell_text": "Pre HD | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 5,
      "source_page": 36,
      "activity_name": "PK (SDA + 10 min)",
      "activity_name_source": {
        "cell_text": "SDA +\n10 min | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 6,
      "source_page": 36,
      "activity_name": "PK (SDA + 30 min)",
      "activity_name_source": {
        "cell_text": "SDA +\n30 min | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 7,
      "source_page": 36,
      "activity_name": "PK (SDA + 60 min)",
      "activity_name_source": {
        "cell_text": "SDA +\n60 min | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 8,
      "source_page": 36,
      "activity_name": "PK (SDA + 90 min)",
      "activity_name_source": {
        "cell_text": "SDA +\n90 min | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    },
    {
      "table_number": 3,
      "row_position": 9,
      "source_page": 36,
      "activity_name": "PK (SDA + 18 to 30 hr)",
      "activity_name_source": {
        "cell_text": "SDA +\n18 to\n30 hr | PK",
        "indentation_level": 1,
        "indentation_method": "visual_estimate"
      }
    }
  ],
  "activity_schedule": [
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 7,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 19,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 20,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 21,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 4,
      "column_position": 22,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 5,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 5,
      "column_position": 9,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 5,
      "column_position": 12,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 5,
      "column_position": 15,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 5,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 6,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 6,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 7,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 7,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 8,
      "column_position": 5,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 8,
      "column_position": 17,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 9,
      "column_position": 6,
      "cell_value": "X",
      "source_range": ""
    },
    {
      "table_number": 3,
      "row_position": 9,
      "column_position": 18,
      "cell_value": "X",
      "source_range": ""
    }
  ],
  "annotations": [
    {
      "annotation_marker": "a",
      "annotation_type": "footnote",
      "annotation_text": "Definition of footnote 'a' (on the 29/ET column header) is not printed in the source for Table 1c; only the abbreviation line 'HD = hemodialysis; ET = early termination; SDA = Study drug administration.' follows the table. Probable equivalent (NOT source content for this table): Table 1b footnote a - 'If a treated subject withdraws from study before completion of dosing, the investigator will make every effort to obtain day 29 samples as close to 2 days after the last dose of investigational product as possible.'",
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 2,
          "column_position": 19
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D3",
      "severity": "medium",
      "location": {
        "page": 36
      },
      "call_made": "Table 1c is typed 'domain' (same day columns and same participants as Table 1a, PK category).",
      "alternative": "Type it 'subsidiary' (finer PK timing for a subset of activities), since its rows are sampling times relative to dosing.",
      "report_section": "4.1"
    },
    {
      "id": "D4",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_positions": [
          4,
          5,
          6,
          7,
          8,
          9
        ]
      },
      "call_made": "The Time label column value is folded into each activity name: 'PK (Pre HD)', 'PK (SDA + 10 min)', ... 'PK (SDA + 18 to 30 hr)'.",
      "alternative": "Keep every row's name as the printed 'PK' and carry the time value separately (e.g. as a per-row note), accepting six rows with the same name.",
      "report_section": "4.3"
    },
    {
      "id": "D5",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_position": 3
      },
      "call_made": "The 'Central Laboratory' band printed across the day columns is a level-0 section-header row grouping the PK rows (no marks).",
      "alternative": "Treat it as a header property/condition row (where samples are analysed) or as a table-level note rather than an activity row.",
      "report_section": "4.3"
    },
    {
      "id": "D6",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_position": 2,
        "column_position": 19,
        "annotation_marker": "a"
      },
      "call_made": "Marker 'a' on the 29/ET header is kept; its annotation says the definition is not printed for Table 1c and cites Table 1b footnote a as a probable (unasserted) equivalent.",
      "alternative": "Assert Table 1b footnote a's wording as this table's footnote a, or drop the marker as undefined.",
      "report_section": "4.4"
    }
  ]
}