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      "extraction_status": "ready_for_resolution"
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    "validation_results": {
      "structure_valid": true,
      "hierarchy_valid": true,
      "annotations_valid": true,
      "validation_warnings": [],
      "validation_errors": [],
      "method_provenance": [
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    "resolution_notes": ""
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  "extraction_metadata": {
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    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
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      "document_type": "protocol",
      "document_version": "Protocol Number 20140197 (AMG 416)",
      "document_date": "25 May 2018"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Text-layer PDF with vector rule lines; marks verified by pdftotext -bbox column binning against header day-label x-centres and diffed against a visual read (no disagreements). 2 leading label column(s); first data column position 3.",
    "model": "claude-opus-5-5"
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    "table_type": "domain",
    "table_title": "Table 1c. Schedule of Pharmacokinetic Assessments",
    "table_purpose": "Pharmacokinetic sampling by time relative to hemodialysis / study drug administration, on the shared Screening-Day 55 timeline",
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    "page_end": 36,
    "track_label": null,
    "column_count": 20,
    "row_count": 9,
    "header_row_count": 2,
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    "notes": "Classified domain rather than subsidiary: it prints exactly the same day columns as Tables 1a/1b (not a finer column structure) for the same participants, and its finer timing lives in the rows (Time label column: Pre HD, SDA + 10/30/60/90 min, SDA + 18 to 30 hr). Two leading label columns (Time, Assessment); data columns 3-22. The Time value is folded into activity_name to keep the six 'PK' rows distinct. 'Central Laboratory' band spanning the data columns is taken as a level-0 section header. Marker 'a' on the 29/ET header has no footnote printed with this table."
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      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-003",
      "column_id": "col-009",
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      "column_position": 9,
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      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-003",
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      "column_position": 12,
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      "cell_value_type": "marker",
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      "annotation_markers": "",
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    },
    {
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      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
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      "annotation_markers": "",
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    },
    {
      "activity_id": "act-004",
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      "cell_value_type": "marker",
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      "annotation_markers": "",
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    },
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    },
    {
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    },
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    },
    {
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    },
    {
      "activity_id": "act-007",
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  ],
  "annotations": [
    {
      "annotation_id": "annot-001",
      "table_id": "table-003",
      "annotation_marker": "a",
      "annotation_type": "footnote",
      "annotation_text": "Definition of footnote 'a' (on the 29/ET column header) is not printed in the source for Table 1c; only the abbreviation line 'HD = hemodialysis; ET = early termination; SDA = Study drug administration.' follows the table. Probable equivalent (NOT source content for this table): Table 1b footnote a - 'If a treated subject withdraws from study before completion of dosing, the investigator will make every effort to obtain day 29 samples as close to 2 days after the last dose of investigational product as possible.'",
      "annotation_scope": "column",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [
          "col-019"
        ],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 2,
          "column_position": 19
        }
      ],
      "document_references": [
        {
          "kind": "table",
          "target": "1"
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D3",
      "severity": "medium",
      "location": {
        "page": 36
      },
      "call_made": "Table 1c is typed 'domain' (same day columns and same participants as Table 1a, PK category).",
      "alternative": "Type it 'subsidiary' (finer PK timing for a subset of activities), since its rows are sampling times relative to dosing.",
      "report_section": "4.1"
    },
    {
      "id": "D4",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_positions": [
          4,
          5,
          6,
          7,
          8,
          9
        ]
      },
      "call_made": "The Time label column value is folded into each activity name: 'PK (Pre HD)', 'PK (SDA + 10 min)', ... 'PK (SDA + 18 to 30 hr)'.",
      "alternative": "Keep every row's name as the printed 'PK' and carry the time value separately (e.g. as a per-row note), accepting six rows with the same name.",
      "report_section": "4.3"
    },
    {
      "id": "D5",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_position": 3
      },
      "call_made": "The 'Central Laboratory' band printed across the day columns is a level-0 section-header row grouping the PK rows (no marks).",
      "alternative": "Treat it as a header property/condition row (where samples are analysed) or as a table-level note rather than an activity row.",
      "report_section": "4.3"
    },
    {
      "id": "D6",
      "severity": "medium",
      "location": {
        "page": 36,
        "row_position": 2,
        "column_position": 19,
        "annotation_marker": "a"
      },
      "call_made": "Marker 'a' on the 29/ET header is kept; its annotation says the definition is not printed for Table 1c and cites Table 1b footnote a as a probable (unasserted) equivalent.",
      "alternative": "Assert Table 1b footnote a's wording as this table's footnote a, or drop the marker as undefined.",
      "report_section": "4.4"
    }
  ]
}