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      "annotation_text": "Patients must be non-germline BRCA mutated to be enrolled into the study. Patients for whom their gBRCA status is already known should be consented to the study within 28 days prior to Day 1 of study treatment. Patients who do not know their mutation status will need BRCA1/2 mutation screening (see Section 4.1.1 and Appendix F).",
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      "annotation_text": "If assessed within 7 days before first dose and meets the stated eligibility criteria (if applicable), it does not need to be repeated on Day 1 of study treatment unless Investigator believes that it is likely to have changed significantly.",
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          "marker": "c",
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          "marker": "e",
          "annotation_id": "annot-005"
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          "marker": "f",
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      "annotation_text": "Unless patient was tested at Myriad as part of screening. All patients are required to provide a 9 ml blood sample for confirmation of gBRCA status. Please refer to the laboratory manual for further details regarding blood sample collection,shipping and storage.",
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          "marker": "g",
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          "marker": "j",
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          "table_num": 2,
          "marker": "k",
          "annotation_id": "annot-010"
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      "xannot_id": "xannot-019",
      "annotation_type": "footnote",
      "annotation_text": "Patient will be followed (can be by phone or email) regularly until start of subsequent therapy; survival will be followed at approximately 12 weekly intervals thereafter.",
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        {
          "table_num": 2,
          "marker": "l",
          "annotation_id": "annot-011"
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  ],
  "review_items": [
    {
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      "id": "D1",
      "severity": "medium",
      "location": {
        "page": 41,
        "row_position": 16,
        "annotation_marker": "n1"
      },
      "call_made": "The unmarked line 'Note: MRI/ CT scan more than 28 days prior to Day 1 may be acceptable...' printed directly under footnote e is kept as its own footnote (synthesised marker n1) and attached to the Tumour assessment row by proximity to footnote e.",
      "alternative": "Treat the Note as the tail of footnote e (append its text to e and drop n1), or leave it unattached as a table-level note.",
      "report_section": "2.3"
    },
    {
      "table_number": 1,
      "id": "D2",
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      "location": {
        "page": 40
      },
      "call_made": "Table 1 (screening) and Table 2 (on-study) are both typed main_soa, as two independent schedules with different columns for the same participants.",
      "alternative": "Type Table 1 as the single main_soa and Table 2 as a track (treatment/follow-up phase), or vice versa.",
      "report_section": "1"
    }
  ]
}