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          "target": "4.1.1"
        },
        {
          "kind": "appendix",
          "target": "F"
        }
      ]
    },
    {
      "annotation_id": "annot-005",
      "table_id": "table-001",
      "annotation_marker": "e",
      "annotation_type": "footnote",
      "annotation_text": "Includes CA-125 measurement where required (Refer to Inclusion Criterion 6). RECIST assessment should be performed no more than 28 days before the start of study treatment, and ideally should be performed as close as possible to the start of study treatment.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-015"
        ],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 1,
          "location_type": "activity_name",
          "row_position": 16
        }
      ]
    },
    {
      "annotation_id": "annot-006",
      "table_id": "table-001",
      "annotation_marker": "n1",
      "annotation_type": "footnote",
      "annotation_text": "Note: MRI/ CT scan more than 28 days prior to Day 1 may be acceptable, please consult with AstraZeneca.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-015"
        ],
        "cell_references": []
      },
      "marker_locations": [
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          "row_position": 16,
          "method": "proximity"
        }
      ]
    },
    {
      "annotation_id": "annot-007",
      "table_id": "table-001",
      "annotation_marker": "f",
      "annotation_type": "footnote",
      "annotation_text": "These measurements may be repeated within the screening period if abnormalities are found which are the only reason for screen failing the patient and which can reasonably be expected to have return to the acceptable range",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
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        "cell_references": []
      },
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        }
      ]
    },
    {
      "annotation_id": "annot-008",
      "table_id": "table-001",
      "annotation_marker": "g",
      "annotation_type": "footnote",
      "annotation_text": "All patients are required to submit either an archival tumour sample, or a fresh biopsy if an archival sample is not available, for retrospective testing of their genetic status. If archival tissue, the presence of adequate tissue needs to be confirmed prior to screening, but it will not be shipped to the central lab before Day1. If fresh, the biopsy should be taken after the baseline scan has been performed. Samples should be submitted as paraffin blocks, alternatively, sections mounted on glass slides prepared from the block can be provided. Please refer to the laboratory manual for further details regarding tissue collection, shipping and storage.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
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        "cell_references": []
      },
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  ],
  "review_items": [
    {
      "id": "D1",
      "severity": "medium",
      "location": {
        "page": 41,
        "row_position": 16,
        "annotation_marker": "n1"
      },
      "call_made": "The unmarked line 'Note: MRI/ CT scan more than 28 days prior to Day 1 may be acceptable...' printed directly under footnote e is kept as its own footnote (synthesised marker n1) and attached to the Tumour assessment row by proximity to footnote e.",
      "alternative": "Treat the Note as the tail of footnote e (append its text to e and drop n1), or leave it unattached as a table-level note.",
      "report_section": "2.3"
    },
    {
      "id": "D2",
      "severity": "medium",
      "location": {
        "page": 40
      },
      "call_made": "Table 1 (screening) and Table 2 (on-study) are both typed main_soa, as two independent schedules with different columns for the same participants.",
      "alternative": "Type Table 1 as the single main_soa and Table 2 as a track (treatment/follow-up phase), or vice versa.",
      "report_section": "1"
    }
  ]
}