{
  "schema_name": "soa-table-extraction",
  "schema_version": "1.0",
  "extraction_metadata": {
    "extracted_at": "2026-09-27T21:05:00+02:00",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT03637764_soa.pdf",
      "document_type": "protocol",
      "document_version": "Amended Clinical Trial Protocol 05, Version number: 1",
      "document_date": "23-Nov-2020"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Text-layer PDF with vector rule lines. Grid read with pdftotext -bbox, column/row boundaries from rule lines recovered on a 200 dpi render (§1d). One label column (L=1); data columns 2-23. Body rows 9-16 are drawn with vertical rules offset up to ~16 px (200 dpi) from the header rules; body cells assigned to header columns by majority x-overlap. Grey-shaded cells without text carry no entry; '-' is transcribed literally. Abbreviation block on p.23 not extracted (its terms occur only as cell values, never as markers).",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_number": 2,
    "table_type": "subsidiary",
    "table_title": "PHARMACOKINETICS AND IMMUNOGENICITY FLOW CHART",
    "table_purpose": "Per-sample PK and ADA timing (relative to start/end of infusion) for atezolizumab and isatuximab, with IMP infusion timing",
    "page_start": 22,
    "page_end": 23,
    "notes": "Typed subsidiary: the main SoA (Table 01, p.21) carries single rows 'PK' and 'ADA' reading 'See Pharmacokinetics and immunogenicity Flow Chart'; this table breaks those into per-sample IDs on a finer, within-day timepoint grid (SOI/EOI/EOI+Xh). Grid on p.22; footnotes f-j and abbreviations continue on p.23 (no body rows there)."
  },
  "schedule_properties": [
    {
      "table_number": 2,
      "row_position": 1,
      "property_name": "Study Phase",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "Study Phase"
      },
      "property_type": "epoch",
      "property_comment": "Study phase band: 'Treatment Phase' spans all cycle columns (2:21), 'Post-treatment' spans EOT and FUP (22:23). Major study phases -> epoch.",
      "hierarchical_level": 1
    },
    {
      "table_number": 2,
      "row_position": 2,
      "property_name": "Cycle",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "Cycle"
      },
      "property_type": "cycle",
      "property_comment": "Treatment cycles: Cycle 1 (2:10), Cycle 2 (11:13), Cycle 3 (14:15), Cycle 4 (16:19), Subsequent Cycles (20:21); EOT (22) and FUP (90±7 days) (23) are cells vertically merged across this row and the Day row, recorded on this row only. Repeating oncology cycles -> cycle.",
      "hierarchical_level": 2
    },
    {
      "table_number": 2,
      "row_position": 3,
      "property_name": "Day within the Cycle",
      "property_name_source": {
        "row_position": 3,
        "column_position": 1,
        "cell_value": "Day within the Cycle"
      },
      "property_type": "study_day",
      "property_comment": "Day within the cycle: D1 (2:8), D15 (9:10) in Cycle 1; D1 for every later cycle. Columns 22-23 are covered by the vertically merged EOT / FUP cells from the Cycle row. Note the source prints the 72h and 168h (SOI of Day 8) columns under the Cycle 1 'D1' span. Day numbers -> study_day.",
      "hierarchical_level": 3
    },
    {
      "table_number": 2,
      "row_position": 4,
      "property_name": "Sample RNT (h) Ref: SOI Atezolizumab",
      "property_name_source": {
        "row_position": 4,
        "column_position": 1,
        "cell_value": "Sample RNT (h)\nRef: SOI\nAtezolizumab"
      },
      "property_type": "timepoint",
      "property_comment": "Atezolizumab relative nominal sampling times (SOI, EOI, EOI +30 min), referenced to atezolizumab start of infusion; '-' where no atezolizumab timepoint applies. Within-visit timing -> timepoint. Drug-specific: governs the atezolizumab PK/ADA rows. Parallel to row 6 (isatuximab scale); stacked levels 4 and 5 follow print order, not a parent-child relation.",
      "hierarchical_level": 4
    },
    {
      "table_number": 2,
      "row_position": 5,
      "property_name": "Sample time window Atezolizumab",
      "property_name_source": {
        "row_position": 5,
        "column_position": 1,
        "cell_value": "Sample time\nwindow\nAtezolizumab"
      },
      "property_type": "window",
      "property_comment": "Allowed sampling windows for the atezolizumab timepoints in row 4 ([-24h, SOI], ±5 min, ±10 min). Window qualifier of row 4; does not by itself distinguish columns -> level null.",
      "hierarchical_level": null
    },
    {
      "table_number": 2,
      "row_position": 6,
      "property_name": "Sample RNT (h) Ref: SOI Isatuximab",
      "property_name_source": {
        "row_position": 6,
        "column_position": 1,
        "cell_value": "Sample RNT (h)\nRef: SOI Isatuximab"
      },
      "property_type": "timepoint",
      "property_comment": "Isatuximab relative nominal sampling times (SOI, EOI, EOI +4h, 72h, 168h (SOI of Day 8), EOI +1h), referenced to isatuximab start of infusion; '-' where no isatuximab timepoint applies. Within-visit timing -> timepoint. Drug-specific: governs the isatuximab PK/ADA rows. Parallel to row 4; this row carries the finest column split of the table.",
      "hierarchical_level": 5
    },
    {
      "table_number": 2,
      "row_position": 7,
      "property_name": "Sample time window Isatuximab",
      "property_name_source": {
        "row_position": 7,
        "column_position": 1,
        "cell_value": "Sample time\nwindow Isatuximab"
      },
      "property_type": "window",
      "property_comment": "Allowed sampling windows for the isatuximab timepoints in row 6 (±10 min, ±30 min, ±5 h, [-24h, SOI]). Window qualifier of row 6 -> level null.",
      "hierarchical_level": null
    }
  ],
  "schedule_grid": [
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 2,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 3,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 4,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 5,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 6,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 7,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 8,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 9,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 10,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 11,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 12,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 13,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 14,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 15,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 16,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 17,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 18,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 19,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 20,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 21,
      "cell_value": "Treatment Phase",
      "is_merged_cell": true,
      "merged_cell_range": "2:21"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 22,
      "cell_value": "Post-treatment",
      "is_merged_cell": true,
      "merged_cell_range": "22:23"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 23,
      "cell_value": "Post-treatment",
      "is_merged_cell": true,
      "merged_cell_range": "22:23"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 2,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 3,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 4,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 5,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 6,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 7,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 8,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 9,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 10,
      "cell_value": "Cycle 1",
      "is_merged_cell": true,
      "merged_cell_range": "2:10"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 11,
      "cell_value": "Cycle 2",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 12,
      "cell_value": "Cycle 2",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 13,
      "cell_value": "Cycle 2",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 14,
      "cell_value": "Cycle 3",
      "is_merged_cell": true,
      "merged_cell_range": "14:15"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 15,
      "cell_value": "Cycle 3",
      "is_merged_cell": true,
      "merged_cell_range": "14:15"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 16,
      "cell_value": "Cycle 4",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 17,
      "cell_value": "Cycle 4",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 18,
      "cell_value": "Cycle 4",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 19,
      "cell_value": "Cycle 4",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 20,
      "cell_value": "Subsequent Cycles",
      "is_merged_cell": true,
      "merged_cell_range": "20:21"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 21,
      "cell_value": "Subsequent Cycles",
      "is_merged_cell": true,
      "merged_cell_range": "20:21"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 22,
      "cell_value": "EOT"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 23,
      "cell_value": "FUP (90±7 days)"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 2,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 3,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 4,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 5,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 6,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 7,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 8,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "2:8"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 9,
      "cell_value": "D15",
      "is_merged_cell": true,
      "merged_cell_range": "9:10"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 10,
      "cell_value": "D15",
      "is_merged_cell": true,
      "merged_cell_range": "9:10"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 11,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 12,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 13,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "11:13"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 14,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "14:15"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 15,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "14:15"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 16,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 17,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 18,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 19,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "16:19"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 20,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "20:21"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 21,
      "cell_value": "D1",
      "is_merged_cell": true,
      "merged_cell_range": "20:21"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 2,
      "cell_value": "SOI"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 3,
      "cell_value": "EOI"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 4,
      "cell_value": "EOI +30 min"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 5,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 6,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 7,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 8,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 9,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 10,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "5:10"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 11,
      "cell_value": "SOI"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 12,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 13,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 14,
      "cell_value": "SOI"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 15,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 16,
      "cell_value": "SOI"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 17,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 18,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 19,
      "cell_value": "-",
      "is_merged_cell": true,
      "merged_cell_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 20,
      "cell_value": "SOI"
    },
    {
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    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 19,
      "cell_value": "P02"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 20,
      "cell_value": "P00",
      "annotation_markers": "b,g"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 21,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 22,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 23,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 2,
      "cell_value": "AS00"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 3,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 4,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 5,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 6,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 7,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 8,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 9,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 10,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 11,
      "cell_value": "AS00"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 12,
      "cell_value": "-",
      "source_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 13,
      "cell_value": "-",
      "source_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 14,
      "cell_value": "AS00"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 15,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 16,
      "cell_value": "AS00"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 17,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 18,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 19,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 20,
      "cell_value": "AS00",
      "annotation_markers": "j"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 21,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 22,
      "cell_value": "ASF00"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 23,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 2,
      "cell_value": "AP00",
      "annotation_markers": "b"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 3,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 4,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 5,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 6,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 7,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 8,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 9,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 10,
      "cell_value": "-",
      "source_range": "3:10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 11,
      "cell_value": "AP00",
      "annotation_markers": "b"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 12,
      "cell_value": "-",
      "source_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 13,
      "cell_value": "-",
      "source_range": "12:13"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 14,
      "cell_value": "AP00",
      "annotation_markers": "b"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 15,
      "cell_value": "-"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 16,
      "cell_value": "AP00",
      "annotation_markers": "b"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 17,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 18,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 19,
      "cell_value": "-",
      "source_range": "17:19"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 20,
      "cell_value": "AP00",
      "annotation_markers": "b"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 21,
      "cell_value": "-",
      "source_range": "21:22"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 22,
      "cell_value": "-",
      "source_range": "21:22"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "column_position": 23,
      "cell_value": "APF00",
      "annotation_markers": "h"
    }
  ],
  "annotations": [
    {
      "annotation_marker": "a",
      "annotation_type": "source_note",
      "annotation_text": "Refer to the laboratory manual for sample collection, processing and shipping.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 11
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 14
        }
      ]
    },
    {
      "annotation_marker": "b",
      "annotation_type": "footnote",
      "annotation_text": "Isatuximab PK or ADA predose samples should be collected before isatuximab administration and at the same time as atezolizumab predose samples when applicable.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 2
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 11
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 14
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 20
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 2
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 11
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 14
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 20
        }
      ]
    },
    {
      "annotation_marker": "c",
      "annotation_type": "footnote",
      "annotation_text": "Atezolizumab sample collected strictly before the start of atezolizumab infusion (during treatment phase).",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 15
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 12,
          "column_position": 11
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 12,
          "column_position": 14
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 12,
          "column_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 12,
          "column_position": 20
        }
      ]
    },
    {
      "annotation_marker": "d",
      "annotation_type": "footnote",
      "annotation_text": "P04 sample must be collected even if the participant withdraws the study without receiving the second administration of isatuximab.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 8
        }
      ]
    },
    {
      "annotation_marker": "e",
      "annotation_type": "footnote",
      "annotation_text": "After start of study treatment, if 1 drug is prematurely discontinued, ADA samples for this drug will be collected and tested on Day 1 of the 2 next cycles. The ADA sample collection for other drug should be done as planned.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 14
        }
      ]
    },
    {
      "annotation_marker": "f",
      "annotation_type": "footnote",
      "annotation_text": "Sample collected just before actual end of infusion of isatuximab.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 5
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 10
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 13
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 18
        }
      ]
    },
    {
      "annotation_marker": "g",
      "annotation_type": "footnote",
      "annotation_text": "Isatuximab sample collected strictly before the start of isatuximab infusion (during treatment phase).",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 8
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 9
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 11
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 14
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 13,
          "column_position": 20
        }
      ]
    },
    {
      "annotation_marker": "h",
      "annotation_type": "footnote",
      "annotation_text": "After FUP 90(±7) days after last isatuximab administration no further ADA will be sampled even if the status is positive or inconclusive.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 16
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 16,
          "column_position": 23
        }
      ]
    },
    {
      "annotation_marker": "i",
      "annotation_type": "footnote",
      "annotation_text": "Isatuximab PK and ADA samples to be collected each cycle until the last study treatment for PK and until FUP 90(±7) days after last IMP administration for ADA or at the cut-off date, whichever comes first. However, collection can be reduced or stopped earlier upon notification from the Sponsor based on the updated knowledge of isatuximab on PK/ADA.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 11
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 13
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 14
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 16
        }
      ]
    },
    {
      "annotation_marker": "j",
      "annotation_type": "footnote",
      "annotation_text": "For subsequent cycles, atezolizumab PK and ADA samples (pre-dose) are to be collected at Cycle 8 Day 1 and Cycle 16 Day 1 only.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 12
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 15
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 12,
          "column_position": 20
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 15,
          "column_position": 20
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D7",
      "severity": "medium",
      "location": {
        "page": 22,
        "row_positions": [
          4,
          5,
          6,
          7
        ]
      },
      "call_made": "The four drug-specific rows 'Sample RNT (h)' and 'Sample time window' (atezolizumab, isatuximab) are header rows (schedule properties): RNT rows as timepoint at levels 4 (atezolizumab) and 5 (isatuximab), window rows as window with no level.",
      "alternative": "Treat the two RNT rows as parallel scales at the same level (or as per-drug activity-level timing), since neither is the parent of the other.",
      "report_section": "2.3"
    },
    {
      "id": "D8",
      "severity": "high",
      "location": {
        "page": 22,
        "row_position": 10
      },
      "call_made": "Isatuximab infusion marks are placed in the columns their drawn cells cover: Cycle 1 D1 bar in columns 4-5, Cycle 2 bar in 12-13, Cycle 3 'X' in 15, Cycle 4 bar in 17-18, Subsequent Cycles 'X' in 21. In Cycles 2-4 and Subsequent these columns sit one column right of the isatuximab 'SOI' column.",
      "alternative": "Realign each isatuximab infusion mark to start at the isatuximab SOI column of its cycle (columns 2, 11, 14, 16, 20).",
      "report_section": "2.4"
    },
    {
      "id": "D9",
      "severity": "medium",
      "location": {
        "page": 22,
        "row_positions": [
          12,
          13
        ]
      },
      "call_made": "PK rows named with the full two-line label: 'Atezolizumab Sample ID' and 'Isatuximab Sample ID'.",
      "alternative": "Name them 'Atezolizumab' / 'Isatuximab' and treat 'Sample ID' as a caption saying the cells hold sample identifiers.",
      "report_section": "2.5"
    },
    {
      "id": "D10",
      "severity": "low",
      "location": {
        "page": 22,
        "row_positions": [
          2,
          3
        ]
      },
      "call_made": "Header cells merged vertically over two header rows are recorded on the upper row only: Table 02 'EOT' and 'FUP (90±7 days)' on the Cycle row (Day row empty in columns 22-23); Table 03 'Screening' on the Study phase row (Cycle/visit row empty in column 4).",
      "alternative": "Repeat the vertically merged value on each covered header row.",
      "report_section": "2.2 / 3.2"
    }
  ]
}