{
  "schema_name": "soa-table-resolved",
  "schema_version": "1.2",
  "resolution_metadata": {
    "resolved_at": "2026-10-03T15:50:57.477389+00:00",
    "resolver": "soa2usdm.steps.resolve v1.0",
    "source_extraction": {
      "schema_name": "soa-table-extraction",
      "schema_version": "1.0",
      "extraction_file": "NCT03693430_Table_01_extraction.verified.json",
      "extraction_status": "ready_for_resolution"
    },
    "validation_results": {
      "structure_valid": true,
      "hierarchy_valid": true,
      "annotations_valid": true,
      "validation_warnings": [],
      "validation_errors": [],
      "method_provenance": [
        "activity_name:visual_transcription: 63",
        "annotation_text:visual_transcription: 30",
        "grid_cell:visual_read: 136",
        "indentation_level:visual_estimate: 63",
        "marker_location:synthesized: 52",
        "property_structure:inferred_from_layout: 1",
        "schedule_cell:raster_pixel_detection: 470"
      ]
    },
    "resolution_status": "resolved",
    "ready_for_integration": true,
    "resolution_notes": ""
  },
  "extraction_metadata": {
    "extracted_at": "2026-09-27T13:08:13+00:00",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT03693430_soa.pdf",
      "document_type": "protocol",
      "document_version": "3.0",
      "document_date": "29 June 2018"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Image-only PDF (each page a single 150-ppi raster, no text layer, no vector rules). Rule lines recovered from the raster (vertical rules by column ink fraction, horizontal rules by row ink fraction > 85%); marks detected by near-black pixel counts (<90) per cell (empty cells 0, marks 28-56) and validated against visual reads of every row. All text visually transcribed. Header rows reprinted on pages 10-12 de-duplicated. One label column (L=1); data columns 2-35 = V1..V34. Trial NN9536-4378.",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_id": "table-001",
    "table_number": 1,
    "table_type": "main_soa",
    "table_title": "Flowchart",
    "table_purpose": "Main schedule of activities: screening, randomisation, dose escalation, maintenance, end of treatment and end of trial",
    "page_start": 9,
    "page_end": 12,
    "track_label": null,
    "column_count": 34,
    "row_count": 67,
    "header_row_count": 4,
    "activity_row_count": 63,
    "notes": "Single printed table (\"2 Flowchart\") running over document pages 9-12 under a reprinted header; one table, not continuations. Page 11 and 12 each open with one activity row printed above the reprinted Visit/Timing/Window rows."
  },
  "schedule_properties": [
    {
      "property_id": "prop-001",
      "table_id": "table-001",
      "row_position": 1,
      "property_name": "Period",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "",
        "synthesized": true
      },
      "property_type": "epoch",
      "property_comment": "Top header band (label cell empty): study periods Screening (V1), Randomisation (V2), Dose escalation period (P3-V10, merged), Maintenance period (P11-V32, merged), End of treatment (V33), End of trial (V34). Typed epoch because the values name study phases; name synthesised. Merge extents taken from raster vertical-rule gaps.",
      "hierarchical_level": 1,
      "parent_property_id": null,
      "child_property_ids": [
        "prop-002"
      ],
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "property_id": "prop-002",
      "table_id": "table-001",
      "row_position": 2,
      "property_name": "Visit (V), Phone(P)",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "Visit (V), Phone(P)"
      },
      "property_type": "visit",
      "property_comment": "Visit identifiers V1-V34; prefix V = site visit, P = phone contact (per the row label). Unique per column, so typed visit.",
      "hierarchical_level": 2,
      "parent_property_id": "prop-001",
      "child_property_ids": [
        "prop-003"
      ],
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "property_id": "prop-003",
      "table_id": "table-001",
      "row_position": 3,
      "property_name": "Timing of Visit (Weeks)",
      "property_name_source": {
        "row_position": 3,
        "column_position": 1,
        "cell_value": "Timing of Visit (Weeks)"
      },
      "property_type": "week",
      "property_comment": "Planned visit timing in weeks relative to randomisation (-1 to 111). Label printed \"Timing of visit (Weeks)\" (lower-case v) on the page-12 reprint. Typed week.",
      "hierarchical_level": 3,
      "parent_property_id": "prop-002",
      "child_property_ids": [],
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "property_id": "prop-004",
      "table_id": "table-001",
      "row_position": 4,
      "property_name": "Visit Window (Days)",
      "property_name_source": {
        "row_position": 4,
        "column_position": 1,
        "cell_value": "Visit Window (Days)"
      },
      "property_type": "window",
      "property_comment": "Allowed visit window in days (-7 to 0, 0, ±3, 0 to +5). Typed window; hierarchical_level null because it does not distinguish any column from another. V33 prints ±3 on pages 9-10 but ±5 on the page 11-12 reprints; ±3 (first print) recorded, see review item D1.",
      "hierarchical_level": null,
      "parent_property_id": null,
      "child_property_ids": [],
      "annotation_markers": "",
      "linked_annotation_ids": []
    }
  ],
  "schedule_columns": [
    {
      "column_id": "col-002",
      "table_id": "table-001",
      "column_position": 2,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Screening",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V1",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "-1",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "-7 to 0",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Screening / V1 / -1 / -7 to 0",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-003",
      "table_id": "table-001",
      "column_position": 3,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Randomisation",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V2",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "0",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "0",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Randomisation / V2 / 0 / 0",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-004",
      "table_id": "table-001",
      "column_position": 4,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P3",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "2",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / P3 / 2 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-005",
      "table_id": "table-001",
      "column_position": 5,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V4",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "4",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / V4 / 4 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-006",
      "table_id": "table-001",
      "column_position": 6,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P5",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "6",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / P5 / 6 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-007",
      "table_id": "table-001",
      "column_position": 7,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V6",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "8",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / V6 / 8 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-008",
      "table_id": "table-001",
      "column_position": 8,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P7",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "10",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / P7 / 10 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-009",
      "table_id": "table-001",
      "column_position": 9,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V8",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "12",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / V8 / 12 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-010",
      "table_id": "table-001",
      "column_position": 10,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P9",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "14",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / P9 / 14 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-011",
      "table_id": "table-001",
      "column_position": 11,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Dose escalation period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V10",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "16",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Dose escalation period / V10 / 16 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-012",
      "table_id": "table-001",
      "column_position": 12,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P11",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "18",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / P11 / 18 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-013",
      "table_id": "table-001",
      "column_position": 13,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V12",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "20",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / V12 / 20 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-014",
      "table_id": "table-001",
      "column_position": 14,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P13",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "24",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / P13 / 24 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-015",
      "table_id": "table-001",
      "column_position": 15,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V14",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "28",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / V14 / 28 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-016",
      "table_id": "table-001",
      "column_position": 16,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P15",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "32",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / P15 / 32 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-017",
      "table_id": "table-001",
      "column_position": 17,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V16",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "36",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / V16 / 36 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-018",
      "table_id": "table-001",
      "column_position": 18,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P17",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "40",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / P17 / 40 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-019",
      "table_id": "table-001",
      "column_position": 19,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V18",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "44",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / V18 / 44 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-020",
      "table_id": "table-001",
      "column_position": 20,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "P19",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "48",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / P19 / 48 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-021",
      "table_id": "table-001",
      "column_position": 21,
      "is_label_column": false,
      "column_values": [
        {
          "property_id": "prop-001",
          "value": "Maintenance period",
          "is_merged": true,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-002",
          "value": "V20",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-003",
          "value": "52",
          "is_merged": false,
          "annotation_markers": ""
        },
        {
          "property_id": "prop-004",
          "value": "±3",
          "is_merged": false,
          "annotation_markers": ""
        }
      ],
      "composite_label": "Maintenance period / V20 / 52 / ±3",
      "linked_annotation_ids": []
    },
    {
      "column_id": "col-022",
      "table_id": "table-001",
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}