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      "annotation_text": "All vital sign measurements (i.e., respiratory rate, pulse rate, systolic and diastolic blood pressures, and body temperature), oxygen saturation and NEWS2-specific assessments (i.e., consciousness and presence or absence of oxygen support) should be recorded together twice daily with approximately 12 hours in between while the patient remains hospitalized. If measured more than once during a 12-hour period, the worst values (highest temperature, respiratory rate, and heart rate; lowest blood pressure, oxygen saturation, and consciousness level) during that period should be recorded on the eCRF. Following hospital discharge these parameters should be recorded once at each return visit to the clinic. Vital signs and oxygen saturation will not be recorded if follow-up visits are conducted by telephone.",
      "display_markers": "T2:b",
      "source_occurrences": [
        {
          "table_num": 2,
          "marker": "b",
          "annotation_id": "annot-003"
        }
      ],
      "referenced_xacts": [
        "xact-014",
        "xact-013"
      ],
      "referenced_xcols": [],
      "referenced_props": [],
      "cell_references": [],
      "occurrence_count": 1
    },
    {
      "xannot_id": "xannot-025",
      "annotation_type": "footnote",
      "annotation_text": "If patients are unable to return for onsite visits at Day 35 and/or Day 45, these may be conducted by telephone or home visits. Patients should return to the site for a Day 60 Study Completion visit.",
      "display_markers": "T3:a",
      "source_occurrences": [
        {
          "table_num": 3,
          "marker": "a",
          "annotation_id": "annot-001"
        }
      ],
      "referenced_xacts": [],
      "referenced_xcols": [
        "xcol-033",
        "xcol-034"
      ],
      "referenced_props": [],
      "cell_references": [],
      "occurrence_count": 1
    },
    {
      "xannot_id": "xannot-026",
      "annotation_type": "footnote",
      "annotation_text": "Patients who remain in hospital will have viral load assessed by nasopharyngeal swabs; these will be done if there is evidence of on-going infection.",
      "display_markers": "T3:b",
      "source_occurrences": [
        {
          "table_num": 3,
          "marker": "b",
          "annotation_id": "annot-002"
        }
      ],
      "referenced_xacts": [
        "xact-025"
      ],
      "referenced_xcols": [],
      "referenced_props": [],
      "cell_references": [],
      "occurrence_count": 1
    },
    {
      "xannot_id": "xannot-027",
      "annotation_type": "footnote",
      "annotation_text": "For patients who remain in hospital, vital sign measurements and NEWS2-specific assessments should be conducted twice daily. Following hospital discharge, these parameters should be recorded once at each return visit to the clinic. Vital signs and oxygen saturation will not be recorded if follow-up visits are conducted by telephone.",
      "display_markers": "T3:c",
      "source_occurrences": [
        {
          "table_num": 3,
          "marker": "c",
          "annotation_id": "annot-003"
        }
      ],
      "referenced_xacts": [
        "xact-014",
        "xact-013"
      ],
      "referenced_xcols": [],
      "referenced_props": [],
      "cell_references": [],
      "occurrence_count": 1
    },
    {
      "xannot_id": "xannot-028",
      "annotation_type": "footnote",
      "annotation_text": "Hematology includes WBC count, RBC count, hemoglobin, hematocrit, platelet count, differential count (neutrophils, eosinophils, basophils, monocytes, lymphocytes), and lymphocyte subsets (T cells, B cells, and NK cells). Hematology labs will not be performed if follow-up visits are conducted by telephone.",
      "display_markers": "T3:g",
      "source_occurrences": [
        {
          "table_num": 3,
          "marker": "g",
          "annotation_id": "annot-007"
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      ],
      "referenced_xacts": [
        "xact-018"
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      "referenced_xcols": [],
      "referenced_props": [],
      "cell_references": [],
      "occurrence_count": 1
    },
    {
      "xannot_id": "xannot-029",
      "annotation_type": "footnote",
      "annotation_text": "Chemistry panel (serum or plasma) includes bicarbonate or total carbon dioxide (if considered standard of care for the region), sodium, potassium, chloride, glucose, BUN or urea, creatinine, total protein, albumin, phosphorus, calcium, total bilirubin, ALP, ALT, and/or AST, uric acid, LDH, ferritin, and D-dimer. Chemistry labs will not be performed if follow-up visits are conducted by telephone.",
      "display_markers": "T3:h",
      "source_occurrences": [
        {
          "table_num": 3,
          "marker": "h",
          "annotation_id": "annot-008"
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      "referenced_xacts": [
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      "referenced_xcols": [],
      "referenced_props": [],
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  ],
  "review_items": [
    {
      "table_number": 1,
      "id": "D1",
      "severity": "medium",
      "location": {
        "page": 78,
        "row_positions": [
          25,
          26,
          27,
          28,
          29,
          30,
          31
        ]
      },
      "call_made": "In all three tables the rows printed below the bold/underlined 'Central Labs' header row (to the end of the table) are recorded as children of that header (indentation level 1); every other row is top level (0). The source prints no visual indent.",
      "alternative": "Treat the table as flat: all rows at level 0, with 'Central Labs' as a mark-free level-0 row that does not group the rows beneath it.",
      "report_section": "4.1"
    },
    {
      "table_number": 1,
      "id": "D2",
      "severity": "high",
      "location": {
        "page": 77,
        "row_position": 15
      },
      "call_made": "The PaO2/FiO2 cell '← Optional →' drawn across the merged Day 1-Day 2 columns is distributed as the value '← Optional →' on each covered column (Table 1 columns 3-6; Table 2 columns 2-27, plus a separate 'Optional' at column 28).",
      "alternative": "Treat 'Optional' as a condition on the activity (a note) rather than as a scheduled value in each column, leaving those cells unscheduled.",
      "report_section": "4.2"
    },
    {
      "table_number": 1,
      "id": "D3",
      "severity": "medium",
      "location": {
        "page": 77,
        "row_position": 1
      },
      "call_made": "The top header band ('Screening' | 'Baseline' | blank over columns 4-6) is typed epoch, with a synthesized name 'Study Period'; the blank merged cell over the Day 1 post-dose and Day 2 columns is left empty.",
      "alternative": "Type the band as visit ('Baseline' is a visit name), or treat the blank span as an unlabelled treatment epoch.",
      "report_section": "4.3"
    },
    {
      "table_number": 2,
      "id": "D4",
      "severity": "medium",
      "location": {
        "page": 81
      },
      "call_made": "Appendix 2 (Days 3–28) and Appendix 3 (After Day 28) are each typed main_soa: sequential, independently structured schedules for the same participants, like separate Screening and Treatment tables.",
      "alternative": "Type Appendix 2 and/or Appendix 3 as track (same participants in a different study phase, own visit structure) with a short track_label such as 'Days 3–28' / 'After Day 28'.",
      "report_section": "5.1"
    },
    {
      "table_number": 2,
      "id": "D5",
      "severity": "medium",
      "location": {
        "page": 81,
        "row_position": 1
      },
      "call_made": "The top header band ('Days 3–28' over the daily columns, 'Study Completion/Discontinuation' over the last column) is typed period with a synthesized name 'Period'.",
      "alternative": "Type the band as epoch (follow-up phase vs completion) or as visit (the last cell names a visit).",
      "report_section": "5.2"
    },
    {
      "table_number": 3,
      "id": "D6",
      "severity": "medium",
      "location": {
        "page": 84,
        "row_position": 1
      },
      "call_made": "The top header band (blank over Days 35/45, 'Study Completion' over Day 60) is typed visit with a synthesized name 'Visit' and hierarchical level 1.",
      "alternative": "Type it as epoch, or give it hierarchical_level null as a qualifier row, since Study Day alone already distinguishes the three columns.",
      "report_section": "6.1"
    }
  ]
}