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    "page_end": 24,
    "notes": "subsidiary (by function): Table 1 rows 'PK' and 'IG' point to Section 1.3.1 ('See Section 1.3.1'); this table gives per-sample cycle/day/timepoint for those two activities, i.e. finer timing for an existing activity, although its rows read 'Sample n' (prompt section 2 PK-sampling note). L=1 label column ('Sample #'); data columns 2-6 transcribed in printed orientation. Abbreviation line (hr, PK) not captured (no in-grid markers)."
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      "annotation_type": "footnote",
      "annotation_text": "Note: If the above time points for unscheduled PK sampling happen to occur at the same time as a scheduled PK time point (see table below), then only the scheduled sample will be taken.",
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "visual_transcription",
        "note": "'General Instructions' paragraphs printed above the table in Section 1.3.1 on page 24 (outside the grid); image-only PDF."
      }
    }
  ],
  "review_items": [
    {
      "id": "D9",
      "severity": "medium",
      "location": {
        "page": 24
      },
      "call_made": "Typed 'subsidiary' and transcribed in its printed orientation: one row per sample ('Sample 1' ... 'Sample 14', 'End of treatment'), with Study Cycle, Day within Cycle and Collection Time Point as data columns 2-4 and the PK / Immunogenicity X marks in columns 5-6 (L=1).",
      "alternative": "Type it 'reference' (rows are samples, not procedures), or treat cols 2-4 as row-label columns (L=4, data starting at col 5), or transpose so samples become timepoint columns and PK / IG collection become the activities.",
      "report_section": "5.1"
    },
    {
      "id": "D10",
      "severity": "low",
      "location": {
        "page": 24,
        "row_positions": [
          2,
          3,
          4,
          5,
          6,
          7,
          8,
          9,
          10,
          11,
          12,
          13,
          14,
          15
        ]
      },
      "call_made": "Sample rows are named 'Sample 1' ... 'Sample 14' by combining the column heading 'Sample #' with the printed number (cell_text keeps the bare number); the last row keeps its printed name 'End of treatment'.",
      "alternative": "Use the bare printed numbers ('1' ... '14') as activity names.",
      "report_section": "5.2"
    },
    {
      "id": "D11",
      "severity": "medium",
      "location": {
        "page": 24,
        "row_position": 1
      },
      "call_made": "The four 'General Instructions' paragraphs printed above the table (applies to all cycle lengths; record date/time; unscheduled PK samples on delay/interruption; scheduled sample takes precedence) are captured as table-scope footnotes g1-g4 anchored to the header row.",
      "alternative": "Leave them out as section prose that is not part of the table.",
      "report_section": "5.3"
    }
  ]
}