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    },
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    },
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      "activity_id": "act-008",
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    },
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      "activity_id": "act-008",
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    },
    {
      "activity_id": "act-008",
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    },
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      "activity_id": "act-009",
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    },
    {
      "activity_id": "act-009",
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      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-009",
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    },
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    },
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      "activity_id": "act-010",
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    },
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      "activity_id": "act-010",
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    },
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      "activity_id": "act-010",
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      "activity_id": "act-010",
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    },
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    },
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    },
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    },
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    },
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    },
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    },
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      "activity_id": "act-014",
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      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-014",
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      "cell_value_type": "other",
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      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
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    },
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    },
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      "activity_id": "act-015",
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      "cell_value_type": "timing_text",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
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      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    },
    {
      "activity_id": "act-015",
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      "source_range": "",
      "annotation_markers": "",
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    }
  ],
  "annotations": [
    {
      "annotation_id": "annot-001",
      "table_id": "table-003",
      "annotation_marker": "g1",
      "annotation_type": "footnote",
      "annotation_text": "The pharmacokinetic sampling table applies to all participants irrespective of 21-day or 28-day cycle length.",
      "annotation_scope": "table",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-002",
      "table_id": "table-003",
      "annotation_marker": "g2",
      "annotation_type": "footnote",
      "annotation_text": "Adequately record the actual collection date and time (24-hour clock; for example, 16:00, not 4 pm) on the requisition form of the sample.",
      "annotation_scope": "table",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-003",
      "table_id": "table-003",
      "annotation_marker": "g3",
      "annotation_type": "footnote",
      "annotation_text": "In case of cycle delay and/or ramucirumab dosing interruption, if possible, collect an additional unscheduled PK samples using the appropriate central lab collection kit:\n• at time as close as possible to the onset of the adverse event (AE) (if the cycle delay or ramucirumab dosing interruption is due to an AE).\n• at the time when ramucirumab dose should have been administered (if there had not been a delay or dose interruption).\n• prior to resuming the ramucirumab dosing after dosing interruption/dosing delay.",
      "annotation_scope": "table",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-004",
      "table_id": "table-003",
      "annotation_marker": "g4",
      "annotation_type": "footnote",
      "annotation_text": "Note: If the above time points for unscheduled PK sampling happen to occur at the same time as a scheduled PK time point (see table below), then only the scheduled sample will be taken.",
      "annotation_scope": "table",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
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          "table_number": 3,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D9",
      "severity": "medium",
      "location": {
        "page": 24
      },
      "call_made": "Typed 'subsidiary' and transcribed in its printed orientation: one row per sample ('Sample 1' ... 'Sample 14', 'End of treatment'), with Study Cycle, Day within Cycle and Collection Time Point as data columns 2-4 and the PK / Immunogenicity X marks in columns 5-6 (L=1).",
      "alternative": "Type it 'reference' (rows are samples, not procedures), or treat cols 2-4 as row-label columns (L=4, data starting at col 5), or transpose so samples become timepoint columns and PK / IG collection become the activities.",
      "report_section": "5.1"
    },
    {
      "id": "D10",
      "severity": "low",
      "location": {
        "page": 24,
        "row_positions": [
          2,
          3,
          4,
          5,
          6,
          7,
          8,
          9,
          10,
          11,
          12,
          13,
          14,
          15
        ]
      },
      "call_made": "Sample rows are named 'Sample 1' ... 'Sample 14' by combining the column heading 'Sample #' with the printed number (cell_text keeps the bare number); the last row keeps its printed name 'End of treatment'.",
      "alternative": "Use the bare printed numbers ('1' ... '14') as activity names.",
      "report_section": "5.2"
    },
    {
      "id": "D11",
      "severity": "medium",
      "location": {
        "page": 24,
        "row_position": 1
      },
      "call_made": "The four 'General Instructions' paragraphs printed above the table (applies to all cycle lengths; record date/time; unscheduled PK samples on delay/interruption; scheduled sample takes precedence) are captured as table-scope footnotes g1-g4 anchored to the header row.",
      "alternative": "Leave them out as section prose that is not part of the table.",
      "report_section": "5.3"
    }
  ]
}