{
  "schema_name": "soa-table-extraction",
  "schema_version": "1.0",
  "extraction_metadata": {
    "extracted_at": "2026-09-27T08:50:05Z",
    "extractor": "Claude, PDF_TO_JSON_PROMPT single-pass",
    "prompt_version": "3.8.1",
    "source_document": {
      "filename": "NCT04677179_soa.pdf",
      "document_type": "protocol",
      "document_version": "J1P-MC-KFAH(b)"
    },
    "extraction_status": "ready_for_resolution",
    "extraction_notes": "Single-pass extraction. Tiled table: marks from both tiles unioned per row. Marks from pdftotext -bbox binned to header column centres, checked visually against renders of every page.",
    "model": "claude-opus-5-5"
  },
  "table_metadata": {
    "table_number": 2,
    "table_type": "track",
    "track_label": "Responders",
    "table_title": "Table 2. Schedule of Activities for the Maintenance Treatment Period of Study J1P-MC-KFAH",
    "table_purpose": "Maintenance treatment period (V10-V29, Weeks 14-52) for participants who are responders at Week 12",
    "page_start": 24,
    "page_end": 32,
    "notes": "Typed track: the source restricts this schedule to responders at Week 12, a population mutually exclusive with Table 3 (nonresponders), even though both use visit numbers V10-V29. Horizontally tiled: pages 24-27 carry V10-V19 and pages 28-32 ('Table 2 (continued)') carry V20-V29 over largely the same body rows; rows unioned, marks merged. L=1; data columns positions 2-21; Comment column emitted as footnote annotations. Rows first printed only in the second tile: Review modified Mayo score (MMS), Diary return, Clinician-Administered Questionnaires (Paper), Physician's Global Assessment (PGA), Endoscopy, Colon biopsy sample collection."
  },
  "schedule_properties": [
    {
      "table_number": 2,
      "row_position": 1,
      "property_name": "Visit number",
      "property_name_source": {
        "row_position": 1,
        "column_position": 1,
        "cell_value": "Visit number"
      },
      "property_type": "visit",
      "property_comment": "Visit identifiers V10-V19 (first column tile, document pages 24-27) and V20-V29 (second tile, headed 'Table 2 (continued)'); property_type visit.",
      "hierarchical_level": 1,
      "annotation_markers": "t1,t2,t3,t4"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "property_name": "Weeks from randomization",
      "property_name_source": {
        "row_position": 2,
        "column_position": 1,
        "cell_value": "Weeks from randomization"
      },
      "property_type": "week",
      "property_comment": "Week offset from randomization, Week 14 to Week 52 in 2-week steps; property_type week.",
      "hierarchical_level": 2
    },
    {
      "table_number": 2,
      "row_position": 3,
      "property_name": "Study day",
      "property_name_source": {
        "row_position": 3,
        "column_position": 1,
        "cell_value": "Study day"
      },
      "property_type": "study_day",
      "property_comment": "Protocol study day, Day 99 to Day 365; property_type study_day.",
      "hierarchical_level": 3
    },
    {
      "table_number": 2,
      "row_position": 4,
      "property_name": "Visit interval tolerance (days)",
      "property_name_source": {
        "row_position": 4,
        "column_position": 1,
        "cell_value": "Visit interval tolerance (days)"
      },
      "property_type": "window",
      "property_comment": "Visit window ±3 days at every visit; property_type window.",
      "hierarchical_level": 4
    },
    {
      "table_number": 2,
      "row_position": 5,
      "property_name": "Fasting visit",
      "property_name_source": {
        "row_position": 5,
        "column_position": 1,
        "cell_value": "Fasting visit"
      },
      "property_type": "other",
      "property_comment": "Shaded header-band row reprinted on every page marking the fasting visits (X at V15 and V29). Visit attribute rather than a timing level, so hierarchical_level null and property_type other.",
      "hierarchical_level": null
    }
  ],
  "schedule_grid": [
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 2,
      "cell_value": "V10",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 3,
      "cell_value": "V11",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 4,
      "cell_value": "V12",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 5,
      "cell_value": "V13",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 6,
      "cell_value": "V14",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 7,
      "cell_value": "V15",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 8,
      "cell_value": "V16",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 9,
      "cell_value": "V17",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 10,
      "cell_value": "V18",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 11,
      "cell_value": "V19",
      "annotation_markers": "t5"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 12,
      "cell_value": "V20",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 13,
      "cell_value": "V21",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 14,
      "cell_value": "V22",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 15,
      "cell_value": "V23",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 16,
      "cell_value": "V24",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 17,
      "cell_value": "V25",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 18,
      "cell_value": "V26",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 19,
      "cell_value": "V27",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 20,
      "cell_value": "V28",
      "annotation_markers": "t6"
    },
    {
      "table_number": 2,
      "row_position": 1,
      "column_position": 21,
      "cell_value": "V29"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 2,
      "cell_value": "14"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 3,
      "cell_value": "16"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 4,
      "cell_value": "18"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 5,
      "cell_value": "20"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 6,
      "cell_value": "22"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 7,
      "cell_value": "24"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 8,
      "cell_value": "26"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 9,
      "cell_value": "28"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 10,
      "cell_value": "30"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 11,
      "cell_value": "32"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 12,
      "cell_value": "34"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 13,
      "cell_value": "36"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 14,
      "cell_value": "38"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 15,
      "cell_value": "40"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 16,
      "cell_value": "42"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 17,
      "cell_value": "44"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 18,
      "cell_value": "46"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 19,
      "cell_value": "48"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 20,
      "cell_value": "50"
    },
    {
      "table_number": 2,
      "row_position": 2,
      "column_position": 21,
      "cell_value": "52"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 2,
      "cell_value": "99"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 3,
      "cell_value": "113"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 4,
      "cell_value": "127"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 5,
      "cell_value": "141"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 6,
      "cell_value": "155"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 7,
      "cell_value": "169"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 8,
      "cell_value": "183"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 9,
      "cell_value": "197"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 10,
      "cell_value": "211"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 11,
      "cell_value": "225"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 12,
      "cell_value": "239"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 13,
      "cell_value": "253"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 14,
      "cell_value": "267"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 15,
      "cell_value": "281"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 16,
      "cell_value": "295"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 17,
      "cell_value": "309"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 18,
      "cell_value": "323"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 19,
      "cell_value": "337"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 20,
      "cell_value": "351"
    },
    {
      "table_number": 2,
      "row_position": 3,
      "column_position": 21,
      "cell_value": "365"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 2,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 3,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 4,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 5,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 6,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 7,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 8,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 9,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 10,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 11,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 12,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 13,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 14,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 15,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 16,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 17,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 18,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 19,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 20,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 4,
      "column_position": 21,
      "cell_value": "±3"
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 2,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 3,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 4,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 5,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 6,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 8,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 9,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 10,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 11,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 12,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 13,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 14,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 15,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 16,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 17,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 18,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 19,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 20,
      "cell_value": ""
    },
    {
      "table_number": 2,
      "row_position": 5,
      "column_position": 21,
      "cell_value": "X"
    }
  ],
  "activities": [
    {
      "table_number": 2,
      "row_position": 6,
      "source_page": 24,
      "activity_name": "Concomitant medications",
      "activity_name_source": {
        "cell_text": "Concomitant medications",
        "indentation_level": 0,
        "indentation_method": "visual_estimate",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 7,
      "source_page": 24,
      "activity_name": "Adverse events",
      "activity_name_source": {
        "cell_text": "Adverse events",
        "indentation_level": 0,
        "indentation_method": "visual_estimate",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c5"
    },
    {
      "table_number": 2,
      "row_position": 8,
      "source_page": 28,
      "activity_name": "Review modified Mayo score (MMS)",
      "activity_name_source": {
        "cell_text": "Review modified Mayo score (MMS)",
        "indentation_level": 0,
        "indentation_method": "visual_estimate",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 9,
      "source_page": 24,
      "activity_name": "Tobacco use",
      "activity_name_source": {
        "cell_text": "Tobacco use",
        "indentation_level": 0,
        "indentation_method": "visual_estimate",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 10,
      "source_page": 24,
      "activity_name": "Physical Evaluation",
      "activity_name_source": {
        "cell_text": "Physical Evaluation",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ],
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 11,
      "source_page": 24,
      "activity_name": "Weight",
      "activity_name_source": {
        "cell_text": "Weight",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 12,
      "source_page": 24,
      "activity_name": "Vital signs",
      "activity_name_source": {
        "cell_text": "Vital signs",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c7"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "source_page": 24,
      "activity_name": "Symptom-directed physical examination, including assessment for signs and symptoms of tuberculosis (TB), including peripheral lymph nodes",
      "activity_name_source": {
        "cell_text": "Symptom-directed physical examination, including assessment for signs and symptoms of tuberculosis (TB), including peripheral lymph nodes",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c9"
    },
    {
      "table_number": 2,
      "row_position": 14,
      "source_page": 24,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 15,
      "source_page": 24,
      "activity_name": "12-lead electrocardiogram (ECG)",
      "activity_name_source": {
        "cell_text": "12-lead electrocardiogram (ECG)",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c10"
    },
    {
      "table_number": 2,
      "row_position": 16,
      "source_page": 24,
      "activity_name": "Patient Diary (Electronic)",
      "activity_name_source": {
        "cell_text": "Patient Diary (Electronic)",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ],
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 17,
      "source_page": 25,
      "activity_name": "Diary compliance check",
      "activity_name_source": {
        "cell_text": "Diary compliance check",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      },
      "annotation_markers": "c12"
    },
    {
      "table_number": 2,
      "row_position": 18,
      "source_page": 29,
      "activity_name": "Diary return",
      "activity_name_source": {
        "cell_text": "Diary return",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 19,
      "source_page": 25,
      "activity_name": "Patient-Reported Outcomes (Electronic)",
      "activity_name_source": {
        "cell_text": "Patient-Reported Outcomes (Electronic)",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ]
      }
    },
    {
      "table_number": 2,
      "row_position": 20,
      "source_page": 25,
      "activity_name": "Inflammatory Bowel Disease Questionnaire (IBDQ)",
      "activity_name_source": {
        "cell_text": "Inflammatory Bowel Disease Questionnaire (IBDQ)",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 21,
      "source_page": 25,
      "activity_name": "Patient Global Impression of Change (PGI-C)",
      "activity_name_source": {
        "cell_text": "Patient Global Impression of Change (PGI-C)",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 22,
      "source_page": 25,
      "activity_name": "QIDS-SR16",
      "activity_name_source": {
        "cell_text": "QIDS-SR16",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 23,
      "source_page": 29,
      "activity_name": "Clinician-Administered Questionnaires (Paper)",
      "activity_name_source": {
        "cell_text": "Clinician-Administered Questionnaires (Paper)",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ]
      }
    },
    {
      "table_number": 2,
      "row_position": 24,
      "source_page": 29,
      "activity_name": "Physician’s Global Assessment (PGA)",
      "activity_name_source": {
        "cell_text": "Physician’s Global Assessment (PGA)",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 25,
      "source_page": 25,
      "activity_name": "Laboratory Tests and Sample Collections",
      "activity_name_source": {
        "cell_text": "Laboratory Tests and Sample Collections",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ]
      }
    },
    {
      "table_number": 2,
      "row_position": 26,
      "source_page": 25,
      "activity_name": "Hematology",
      "activity_name_source": {
        "cell_text": "Hematology",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 27,
      "source_page": 25,
      "activity_name": "Clinical chemistry",
      "activity_name_source": {
        "cell_text": "Clinical chemistry",
        "indentation_level": 1,
        "indentation_method": "font_signal"
      }
    },
    {
      "table_number": 2,
      "row_position": 28,
      "source_page": 26,
      "activity_name": "Lipid panel",
      "activity_name_source": {
        "cell_text": "Lipid panel",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c15"
    },
    {
      "table_number": 2,
      "row_position": 29,
      "source_page": 26,
      "activity_name": "Urinalysis",
      "activity_name_source": {
        "cell_text": "Urinalysis",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 30,
      "source_page": 26,
      "activity_name": "Urine pregnancy (local)",
      "activity_name_source": {
        "cell_text": "Urine pregnancy (local)",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c17"
    },
    {
      "table_number": 2,
      "row_position": 31,
      "source_page": 26,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 32,
      "source_page": 26,
      "activity_name": "HBV DNA",
      "activity_name_source": {
        "cell_text": "HBV DNA",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c22"
    },
    {
      "table_number": 2,
      "row_position": 33,
      "source_page": 26,
      "activity_name": "Pharmacokinetic (PK) samples",
      "activity_name_source": {
        "cell_text": "Pharmacokinetic (PK) samples",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c23"
    },
    {
      "table_number": 2,
      "row_position": 34,
      "source_page": 27,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c23"
    },
    {
      "table_number": 2,
      "row_position": 35,
      "source_page": 27,
      "activity_name": "Flow cytometry panel",
      "activity_name_source": {
        "cell_text": "Flow cytometry panel",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 36,
      "source_page": 27,
      "activity_name": "Genetics sample",
      "activity_name_source": {
        "cell_text": "Genetics sample",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c24"
    },
    {
      "table_number": 2,
      "row_position": 37,
      "source_page": 27,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 38,
      "source_page": 27,
      "activity_name": "Endoscopic Procedure",
      "activity_name_source": {
        "cell_text": "Endoscopic Procedure",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ],
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c30"
    },
    {
      "table_number": 2,
      "row_position": 39,
      "source_page": 31,
      "activity_name": "Endoscopy",
      "activity_name_source": {
        "cell_text": "Endoscopy",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 40,
      "source_page": 31,
      "activity_name": "Colon biopsy sample collection",
      "activity_name_source": {
        "cell_text": "Colon biopsy sample collection",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c26"
    },
    {
      "table_number": 2,
      "row_position": 41,
      "source_page": 27,
      "activity_name": "Stool Samples",
      "activity_name_source": {
        "cell_text": "Stool Samples",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ],
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 42,
      "source_page": 27,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 43,
      "source_page": 27,
      "activity_name": "CCI",
      "activity_name_source": {
        "cell_text": "CCI",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 44,
      "source_page": 27,
      "activity_name": "Randomization and Dosing",
      "activity_name_source": {
        "cell_text": "Randomization and Dosing",
        "indentation_level": 0,
        "indentation_method": "font_signal",
        "text_formatting": [
          "bold"
        ],
        "method": "glyph_reconstruction"
      }
    },
    {
      "table_number": 2,
      "row_position": 45,
      "source_page": 27,
      "activity_name": "Dosing",
      "activity_name_source": {
        "cell_text": "Dosing",
        "indentation_level": 1,
        "indentation_method": "font_signal",
        "method": "glyph_reconstruction"
      },
      "annotation_markers": "c29"
    }
  ],
  "activity_schedule": [
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 2,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 4,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 6,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 8,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 10,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 12,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 14,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 16,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 18,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 20,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 6,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 2,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 4,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 6,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 8,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 10,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 12,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 14,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 16,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 18,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 20,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 7,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 8,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 9,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 9,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 11,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 11,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 2,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 4,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 6,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 8,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 10,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 12,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 14,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 16,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 18,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 20,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 12,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 13,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 14,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 14,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 14,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 15,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 2,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 4,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 6,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 8,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 10,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 12,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 14,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 16,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 18,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 20,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 17,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 18,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 20,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 20,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 21,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 21,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 22,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 22,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 24,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 26,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 27,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 28,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 28,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 29,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 29,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 29,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 29,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 30,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 31,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 31,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 32,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 32,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 32,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 33,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 33,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 33,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 34,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 34,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 34,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 35,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 35,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 37,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 37,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 37,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 39,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 40,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 42,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 42,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 42,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 43,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 43,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 43,
      "column_position": 21,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 2,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 3,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 4,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 5,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 6,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 7,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 8,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 9,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 10,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 11,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 12,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 13,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 14,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 15,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 16,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 17,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 18,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 19,
      "cell_value": "X"
    },
    {
      "table_number": 2,
      "row_position": 45,
      "column_position": 20,
      "cell_value": "X"
    }
  ],
  "annotations": [
    {
      "annotation_marker": "t1",
      "annotation_type": "footnote",
      "annotation_text": "This schedule applies to study participants who are responders at Week 12.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "t2",
      "annotation_type": "source_note",
      "annotation_text": "For procedures at an ETV, see ETV in Table 4.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "t3",
      "annotation_type": "source_note",
      "annotation_text": "For procedures at an early termination visit, see ETV in Table 4.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "t4",
      "annotation_type": "source_note",
      "annotation_text": "For procedures at an unscheduled visit, see V997 in Table 4.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_property",
          "row_position": 1,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "t5",
      "annotation_type": "footnote",
      "annotation_text": "Visits 10 through 28 are eligible to be conducted remotely (that is, by telephone, IT-assisted virtual visit, mobile healthcare, or a combination thereof), if written approval is provided by the sponsor and according to the preferences of the participant and the study site. However, no more than 34 days can elapse without an on-site study visit occurring.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 2,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 3,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 4,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 5,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 6,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 7,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 8,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 9,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 10,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 11,
          "method": "text_match"
        }
      ]
    },
    {
      "annotation_marker": "t6",
      "annotation_type": "footnote",
      "annotation_text": "Visits 10 through 28 are eligible to be conducted remotely (that is, by telephone, IT-assisted virtual visit, mobile healthcare, or a combination thereof) if written approval is provided by the sponsor and according to the preferences of the participant and the study site. However, no more than 34 days can elapse without an on-site study visit occurring.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 12,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 13,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 14,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 15,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 16,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 17,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 18,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 19,
          "method": "text_match"
        },
        {
          "table_number": 2,
          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 20,
          "method": "text_match"
        }
      ]
    },
    {
      "annotation_marker": "c5",
      "annotation_type": "footnote",
      "annotation_text": "For AESIs, additional data are collected (Section 8.3.6).",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 7,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c7",
      "annotation_type": "footnote",
      "annotation_text": "Blood pressure, body temperature, and pulse rate. Vital signs should be measured after participant has been sitting for at least 5 minutes.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 12,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c9",
      "annotation_type": "source_note",
      "annotation_text": "See Section 8.2.2.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 13,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c10",
      "annotation_type": "footnote",
      "annotation_text": "Locally performed.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 15,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c12",
      "annotation_type": "footnote",
      "annotation_text": "Check compliance for\nStool Frequency\nRectal Bleeding\nNocturnal Stools\nBristol Stool Scale\nUrgency NRS\nAbdominal Pain NRS\nFatigue NRS, and\nPatient Global Rating of Severity (PGR-S).",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 17,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "c15",
      "annotation_type": "footnote",
      "annotation_text": "Fasting samples are preferred, but if participant is nonfasting at time of collection, this is not a protocol deviation.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 28,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c17",
      "annotation_type": "footnote",
      "annotation_text": "Perform only for women of childbearing potential and women with a history of tubal ligation. At dosing visits which have pregnancy testing, the pregnancy test result must be confirmed to be negative prior to dosing. Pregnancy testing may be performed more frequently than designated on the SoA, if local laws or regulations require more frequent testing.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 30,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c22",
      "annotation_type": "footnote",
      "annotation_text": "Only for participants who are positive for anti-HBc at screening.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 32,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c23",
      "annotation_type": "footnote",
      "annotation_text": "Collect samples before dosing, if dosing is scheduled. Collect additional samples at specified times relative to onset of hypersensitivity events.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 33,
          "method": "synthesized"
        },
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 34,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c24",
      "annotation_type": "footnote",
      "annotation_text": "Blood sample for DNA pharmacogenetics can be obtained any time at or after V2.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 36,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c26",
      "annotation_type": "footnote",
      "annotation_text": "Performed at time of endoscopy. Instructions for collection are provided in the lab manual. Flexible sigmoidoscopy is recommended, except for protocol-specified reasons when a colonoscopy should be performed.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 40,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    },
    {
      "annotation_marker": "c29",
      "annotation_type": "footnote",
      "annotation_text": "No dosing at V29.",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 45,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_marker": "c30",
      "annotation_type": "footnote",
      "annotation_text": "Not applicable for responders during the time period of V10 through V19",
      "marker_locations": [
        {
          "table_number": 2,
          "location_type": "activity_name",
          "row_position": 38,
          "method": "synthesized"
        }
      ],
      "annotation_text_source": {
        "method": "deglyph_reconstruction",
        "note": "Text rebuilt from glyph-spread text layer over a full-page raster; cell bounds confirmed against the rendered page grid."
      }
    }
  ],
  "review_items": [
    {
      "id": "D4",
      "severity": "medium",
      "location": {
        "page": 24
      },
      "call_made": "Table 2 is typed 'track' (track_label 'Responders') because its population statement restricts it to participants who are responders at Week 12, mutually exclusive with Table 3 (nonresponders).",
      "alternative": "Type it 'main_soa' as an independent maintenance-period schedule.",
      "report_section": "T2.1"
    },
    {
      "id": "D5",
      "severity": "high",
      "location": {
        "page": 28
      },
      "call_made": "'Table 2 (continued)' (pages 28-32, V20-V29) is treated as the second column tile of one horizontally tiled Table 2: rows are unioned by name and marks of both tiles merged into one 20-column table. Redacted 'CCI' rows are matched across tiles by their position between the same named neighbour rows.",
      "alternative": "Extract 'Table 2 (continued)' as a separate continuation table, or match the redacted rows differently (their identity cannot be confirmed from the text).",
      "report_section": "T2.2"
    },
    {
      "id": "D6",
      "severity": "medium",
      "location": {
        "page": 24,
        "row_position": 1,
        "annotation_marker": "t5"
      },
      "call_made": "The title-cell remote-visit note is bound to the Visit number cells it names (tile 1: V10-V19 as t5; tile 2: V20-V28 as t6, V29 excluded because 'Visits 10 through 28'). The tile-2 wording differs only by a missing comma, and the ETV cross-reference is worded differently in tile 2, so the variants are kept as separate annotations.",
      "alternative": "Merge each pair of near-identical tile variants into one annotation and/or bind the remote-visit note to the whole Visit number row.",
      "report_section": "T2.5"
    },
    {
      "id": "D7",
      "severity": "high",
      "location": {
        "page": 27,
        "annotation_marker": "c30"
      },
      "call_made": "The comment 'Not applicable for responders during the time period of V10 through V19' printed on the 'Endoscopic Procedure' section-header row is bound to that header row (activity_name), so it governs the group; its child rows (Endoscopy, Colon biopsy) print only in the V20-V29 tile.",
      "alternative": "Bind the note to the Endoscopy and Colon biopsy sample collection rows, or to the V10-V19 columns.",
      "report_section": "T2.5"
    }
  ]
}