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    {
      "annotation_marker": "c22",
      "annotation_type": "footnote",
      "annotation_text": "Only for participants who are positive for anti-HBc at screening.",
      "marker_locations": [
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          "row_position": 32,
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      ],
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      "annotation_marker": "c23",
      "annotation_type": "footnote",
      "annotation_text": "Collect samples before dosing, if dosing is scheduled. Collect additional samples at specified times relative to onset of hypersensitivity events.",
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          "row_position": 33,
          "method": "synthesized"
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          "location_type": "activity_name",
          "row_position": 34,
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      "annotation_marker": "c24",
      "annotation_type": "footnote",
      "annotation_text": "Blood sample for DNA pharmacogenetics can be obtained any time at or after V2.",
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      ],
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    },
    {
      "annotation_marker": "c26",
      "annotation_type": "footnote",
      "annotation_text": "Performed at time of endoscopy. Instructions for collection are provided in the lab manual. Flexible sigmoidoscopy is recommended, except for protocol-specified reasons when a colonoscopy should be performed.",
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    {
      "annotation_marker": "c29",
      "annotation_type": "footnote",
      "annotation_text": "No dosing at V29.",
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  ],
  "review_items": [
    {
      "id": "D8",
      "severity": "medium",
      "location": {
        "page": 33
      },
      "call_made": "Table 3 is typed 'track' (track_label 'Nonresponders'): it applies only to participants who are nonresponders at Week 12, mutually exclusive with Table 2, although both number their visits V10-V29.",
      "alternative": "Type it 'domain' of Table 2 (same visit columns) or 'main_soa'.",
      "report_section": "T3.1"
    },
    {
      "id": "D9",
      "severity": "high",
      "location": {
        "page": 38
      },
      "call_made": "'Table 3 (continued)' (pages 38-42, V20-V29) is treated as the second column tile of one tiled Table 3; rows unioned by name, redacted 'CCI' rows matched across tiles by position.",
      "alternative": "Extract 'Table 3 (continued)' as a separate continuation table, or match redacted rows differently.",
      "report_section": "T3.2"
    },
    {
      "id": "D10",
      "severity": "medium",
      "location": {
        "page": 33,
        "row_position": 1,
        "annotation_marker": "t5"
      },
      "call_made": "The remote-visit note 'Visits 17 through 28…' is bound to the V17-V19 cells (tile 1, t5) and V20-V28 cells (tile 2, t6; tile-2 text lacks the final period); the V16 multi-day note (t7) is bound to the V16 cell.",
      "alternative": "Bind both notes to the Visit number row as table-wide notes, or merge the two remote-visit variants.",
      "report_section": "T3.5"
    }
  ]
}