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      "activity_id": "act-040",
      "column_id": "col-020",
      "row_position": 45,
      "column_position": 20,
      "cell_value": "X",
      "cell_value_type": "marker",
      "source_range": "",
      "annotation_markers": "",
      "linked_annotation_ids": []
    }
  ],
  "annotations": [
    {
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      ]
    },
    {
      "annotation_id": "annot-002",
      "table_id": "table-003",
      "annotation_marker": "t2",
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      "annotation_text": "For procedures at an ETV, see ETV in Table 4.",
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      ],
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      "annotation_id": "annot-003",
      "table_id": "table-003",
      "annotation_marker": "t4",
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      "annotation_text": "For procedures at an unscheduled visit, see V997 in Table 4.",
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      "annotation_id": "annot-004",
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      },
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        }
      ]
    },
    {
      "annotation_id": "annot-005",
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      "annotation_scope": "column",
      "referenced_elements": {
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        "column_ids": [
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          "col-019",
          "col-020"
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      },
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
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        }
      ]
    },
    {
      "annotation_id": "annot-006",
      "table_id": "table-003",
      "annotation_marker": "t7",
      "annotation_type": "footnote",
      "annotation_text": "V16 procedures may be conducted over more than 1 day as long as all activities are completed within the allowable visit tolerance and all scheduled activities are completed prior to dosing",
      "annotation_scope": "column",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [
          "col-008"
        ],
        "activity_ids": [],
        "cell_references": []
      },
      "marker_locations": [
        {
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          "location_type": "schedule_cell",
          "row_position": 1,
          "column_position": 8,
          "method": "text_match"
        }
      ]
    },
    {
      "annotation_id": "annot-007",
      "table_id": "table-003",
      "annotation_marker": "c5",
      "annotation_type": "footnote",
      "annotation_text": "For AESIs, additional data are collected (Section 8.3.6).",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-002"
        ],
        "cell_references": []
      },
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          "table_number": 3,
          "location_type": "activity_name",
          "row_position": 7,
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        }
      ],
      "document_references": [
        {
          "kind": "section",
          "target": "8.3.6"
        }
      ]
    },
    {
      "annotation_id": "annot-008",
      "table_id": "table-003",
      "annotation_marker": "c7",
      "annotation_type": "footnote",
      "annotation_text": "Blood pressure, body temperature, and pulse rate. Vital signs should be measured after participant has been sitting for at least 5 minutes.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-007"
        ],
        "cell_references": []
      },
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          "location_type": "activity_name",
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        }
      ]
    },
    {
      "annotation_id": "annot-009",
      "table_id": "table-003",
      "annotation_marker": "c9",
      "annotation_type": "source_note",
      "annotation_text": "See Section 8.2.2.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
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        "activity_ids": [
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        ],
        "cell_references": []
      },
      "marker_locations": [
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        }
      ],
      "document_references": [
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          "kind": "section",
          "target": "8.2.2"
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      ]
    },
    {
      "annotation_id": "annot-010",
      "table_id": "table-003",
      "annotation_marker": "c10",
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      "annotation_text": "Locally performed.",
      "annotation_scope": "activity",
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        "activity_ids": [
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        ],
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      },
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        }
      ]
    },
    {
      "annotation_id": "annot-011",
      "table_id": "table-003",
      "annotation_marker": "c12",
      "annotation_type": "footnote",
      "annotation_text": "Check compliance for\nStool Frequency\nRectal Bleeding\nNocturnal Stools\nBristol Stool Scale\nUrgency NRS\nAbdominal Pain NRS\nFatigue NRS, and\nPatient Global Rating of Severity (PGR-S).",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
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        ],
        "cell_references": []
      },
      "marker_locations": [
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          "row_position": 17,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-012",
      "table_id": "table-003",
      "annotation_marker": "c15",
      "annotation_type": "footnote",
      "annotation_text": "Fasting samples are preferred, but if participant is nonfasting at time of collection, this is not a protocol deviation.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
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        ],
        "cell_references": []
      },
      "marker_locations": [
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        }
      ]
    },
    {
      "annotation_id": "annot-013",
      "table_id": "table-003",
      "annotation_marker": "c17",
      "annotation_type": "footnote",
      "annotation_text": "Perform only for women of childbearing potential and women with a history of tubal ligation. At dosing visits which have pregnancy testing, the pregnancy test result must be confirmed to be negative prior to dosing. Pregnancy testing may be performed more frequently than designated on the SoA if local laws or regulations require more frequent testing.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-025"
        ],
        "cell_references": []
      },
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          "row_position": 30,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-014",
      "table_id": "table-003",
      "annotation_marker": "c22",
      "annotation_type": "footnote",
      "annotation_text": "Only for participants who are positive for anti-HBc at screening.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
          "act-027"
        ],
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      },
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          "row_position": 32,
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        }
      ]
    },
    {
      "annotation_id": "annot-015",
      "table_id": "table-003",
      "annotation_marker": "c23",
      "annotation_type": "footnote",
      "annotation_text": "Collect samples before dosing, if dosing is scheduled. Collect additional samples at specified times relative to onset of hypersensitivity events.",
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      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
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          "act-029"
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      },
      "marker_locations": [
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          "location_type": "activity_name",
          "row_position": 34,
          "method": "synthesized"
        }
      ]
    },
    {
      "annotation_id": "annot-016",
      "table_id": "table-003",
      "annotation_marker": "c24",
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      "annotation_text": "Blood sample for DNA pharmacogenetics can be obtained any time at or after V2.",
      "annotation_scope": "activity",
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        "property_ids": [],
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        "activity_ids": [
          "act-031"
        ],
        "cell_references": []
      },
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          "row_position": 36,
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        }
      ]
    },
    {
      "annotation_id": "annot-017",
      "table_id": "table-003",
      "annotation_marker": "c26",
      "annotation_type": "footnote",
      "annotation_text": "Performed at time of endoscopy. Instructions for collection are provided in the lab manual. Flexible sigmoidoscopy is recommended, except for protocol-specified reasons when a colonoscopy should be performed.",
      "annotation_scope": "activity",
      "referenced_elements": {
        "property_ids": [],
        "column_ids": [],
        "activity_ids": [
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      },
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          "row_position": 40,
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        }
      ]
    },
    {
      "annotation_id": "annot-018",
      "table_id": "table-003",
      "annotation_marker": "c29",
      "annotation_type": "footnote",
      "annotation_text": "No dosing at V29.",
      "annotation_scope": "activity",
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        "property_ids": [],
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        "activity_ids": [
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        ],
        "cell_references": []
      },
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          "row_position": 45,
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        }
      ]
    }
  ],
  "review_items": [
    {
      "id": "D8",
      "severity": "medium",
      "location": {
        "page": 33
      },
      "call_made": "Table 3 is typed 'track' (track_label 'Nonresponders'): it applies only to participants who are nonresponders at Week 12, mutually exclusive with Table 2, although both number their visits V10-V29.",
      "alternative": "Type it 'domain' of Table 2 (same visit columns) or 'main_soa'.",
      "report_section": "T3.1"
    },
    {
      "id": "D9",
      "severity": "high",
      "location": {
        "page": 38
      },
      "call_made": "'Table 3 (continued)' (pages 38-42, V20-V29) is treated as the second column tile of one tiled Table 3; rows unioned by name, redacted 'CCI' rows matched across tiles by position.",
      "alternative": "Extract 'Table 3 (continued)' as a separate continuation table, or match redacted rows differently.",
      "report_section": "T3.2"
    },
    {
      "id": "D10",
      "severity": "medium",
      "location": {
        "page": 33,
        "row_position": 1,
        "annotation_marker": "t5"
      },
      "call_made": "The remote-visit note 'Visits 17 through 28…' is bound to the V17-V19 cells (tile 1, t5) and V20-V28 cells (tile 2, t6; tile-2 text lacks the final period); the V16 multi-day note (t7) is bound to the V16 cell.",
      "alternative": "Bind both notes to the Visit number row as table-wide notes, or merge the two remote-visit variants.",
      "report_section": "T3.5"
    }
  ]
}